Ripe fruit of Rubus coreanus inhibits mast cell-mediated allergic inflammation

  • Authors:
    • Hui-Hun Kim
    • Phil Hyung Choi
    • Jin-Su Yoo
    • Hoon Jeon
    • Byeong-Suk Chae
    • Jeong-Suk Park
    • Sang-Hyun Kim
    • Tae-Yong Shin
  • View Affiliations

  • Published online on: November 7, 2011     https://doi.org/10.3892/ijmm.2011.829
  • Pages: 303-310
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Abstract

In this study, we investigated the effect of a water extract of the ripe fruits of Rubus coreanus Miq. (Rosaceae) (RFRC) on mast cell-mediated allergic inflammation and studied the possible mechanism of action. Mast cell-mediated allergic disease is involved in many diseases such as anaphylaxis, rhinitis, asthma and atopic dermatitis. RFRC dose-dependently inhibited compound 48/80-induced systemic anaphylaxis and serum histamine release in mice. RFRC reduced the immunoglobulin E (IgE)-mediated local allergic reaction, passive cutaneous anaphylaxis. RFRC attenuated histamine release from rat peritoneal mast cells and human mast cells by the reduction of intracellular calcium. RFRC decreased the phorbol 12-myristate 13-acetate (PMA) and the calcium ionophore A23187 (PMACI)-stimulated expression and secretion of pro-inflammatory cytokines in human mast cells. The inhibitory effect of RFRC on cytokine production was nuclear factor (NF)-κB- and mitogen-activated protein kinase (MAPK)-dependent. In addition, RFRC suppressed the activation of caspase-1. Our findings provide evidence that RFRC inhibits mast cell-derived allergic inflammatory reactions, and for the involvement of calcium, NF-κB, MAPKs and caspase-1 in these effects. Furthermore, in vivo and in vitro anti-allergic inflammatory effects of RFRC provide affirmative proof of a possible therapeutic application of this agent in allergic inflammatory diseases.

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February 2012
Volume 29 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Kim H, Choi PH, Yoo J, Jeon H, Chae B, Park J, Kim S and Shin T: Ripe fruit of Rubus coreanus inhibits mast cell-mediated allergic inflammation. Int J Mol Med 29: 303-310, 2012
APA
Kim, H., Choi, P.H., Yoo, J., Jeon, H., Chae, B., Park, J. ... Shin, T. (2012). Ripe fruit of Rubus coreanus inhibits mast cell-mediated allergic inflammation. International Journal of Molecular Medicine, 29, 303-310. https://doi.org/10.3892/ijmm.2011.829
MLA
Kim, H., Choi, P. H., Yoo, J., Jeon, H., Chae, B., Park, J., Kim, S., Shin, T."Ripe fruit of Rubus coreanus inhibits mast cell-mediated allergic inflammation". International Journal of Molecular Medicine 29.2 (2012): 303-310.
Chicago
Kim, H., Choi, P. H., Yoo, J., Jeon, H., Chae, B., Park, J., Kim, S., Shin, T."Ripe fruit of Rubus coreanus inhibits mast cell-mediated allergic inflammation". International Journal of Molecular Medicine 29, no. 2 (2012): 303-310. https://doi.org/10.3892/ijmm.2011.829