Potent inhibitory effect of Foeniculum vulgare Miller extract on osteoclast differentiation and ovariectomy-induced bone loss

  • Authors: Tae-Ho Kim, Hyun-Ju Kim, Sang-Han Lee, Shin-Yoon Kim
  • View Affiliations

  • Published online on: Friday, March 23, 2012
  • Pages: 1053-1059
  • DOI: 10.3892/ijmm.2012.950

Abstract

Inhibition of osteoclast differentiation and bone resorption is considered an effective therapeutic approach to the treatment of postmenopausal bone loss. To find natural compounds that may inhibit osteoclastogenesis, we screened herbal extracts on bone marrow cultures. In this study, we found that an aqueous extract of Foeniculum vulgare Miller seed (FvMs) at low concentration, which has traditionally been used as a treatment for a variety of ailments, inhibits the osteoclast differentiation and bone resorptive activity of mature osteoclasts. We further investigated the effects of FvMs on ovariectomy (OVX)-induced bone loss using microcomputed tomography, biomechanical tests and serum marker assays for bone remodeling. Oral administration of FvMs (30 mg or 100 mg/kg/day) for 6 weeks had an intermediary effect on the prevention of femoral bone mineral density (BMD), bone mineral content (BMC), and other parameters compared to OVX controls. In addition, FvMs slightly decreased bone turnover markers that were accelerated by OVX. The bone-protective effects of FvMs may be due to suppression of an OVX-induced increase in bone turnover. Collectively, our findings indicate that FvMs have potential in preventing bone loss in postmenopausal osteoporosis by reducing both osteoclast differentiation and function.
Journal Cover

June 2012
Volume 29 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

2013 Impact Factor: 1.88
Ranked #27/122 Medicine Research and Experimental
(total number of cites)

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APA
Kim, T., Kim, T., Kim, H., Kim, H., Lee, S., Lee, S., Kim, S., & Kim, S. (2012). Potent inhibitory effect of Foeniculum vulgare Miller extract on osteoclast differentiation and ovariectomy-induced bone loss. International Journal of Molecular Medicine, 29(6), 1053-1059.
MLA
Kim, Kim, Kim, Kim, Lee, Lee, Kim, and Shin-Yoon Kim. "Potent inhibitory effect of Foeniculum vulgare Miller extract on osteoclast differentiation and ovariectomy-induced bone loss." International Journal of Molecular Medicine International Journal of Molecular Medicine 29.6 (2012): 1053-1059.
Chicago
Kim, Kim, Kim, Kim, Lee, Lee, Kim, and Shin-Yoon Kim. "Potent inhibitory effect of Foeniculum vulgare Miller extract on osteoclast differentiation and ovariectomy-induced bone loss." International Journal of Molecular Medicine International Journal of Molecular Medicine 29 no. 6 (2012): 1053-1059.