Amorphastilbol exerts beneficial effects on glucose and lipid metabolism in mice consuming a high-fat-diet

  • Authors:
    • Woojung Lee
    • Jungyeob Ham
    • Hak Cheol Kwon
    • Goo Yoon
    • Gyu-Un Bae
    • Yong Kee Kim
    • Su-Nam Kim
  • View Affiliations

  • Published online on: May 29, 2015     https://doi.org/10.3892/ijmm.2015.2227
  • Pages: 527-533
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Abstract

In the present study, the anti-diabetic effects of amorphastilbol (APH) from Amorpha fruticosa (AF) were evaluated in high‑fat‑diet (HFD) mice. HFD‑induced blood glucose and insulin levels are significantly reduced in AF extract or APH treatment groups. HFD‑induced weight gain was reduced by AF treatment, which is accompanied by reduction of fat mass and adipocyte size and number in white adipose tissues. Furthermore, total cholesterol and low‑density lipoprotein‑cholesterol levels are decreased in AF‑ or APH‑treated mice. In addition, AF and APH are able to improve insulin sensitivity through inhibition of protein tyrosine phosphatase 1B, a negative regulator of the insulin‑signaling pathway. Taken together, the data suggest that AF has beneficial effects on glucose and lipid metabolism and its pharmacological effects are driven, in part, by its active component, APH. Therefore, AF and APH can be used as potential therapeutic agents against type 2 diabetes and associated metabolic disorders, including obesity, by enhancing glucose and lipid metabolism.
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August-2015
Volume 36 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Lee W, Ham J, Kwon HC, Yoon G, Bae G, Kim YK and Kim S: Amorphastilbol exerts beneficial effects on glucose and lipid metabolism in mice consuming a high-fat-diet. Int J Mol Med 36: 527-533, 2015
APA
Lee, W., Ham, J., Kwon, H.C., Yoon, G., Bae, G., Kim, Y.K., & Kim, S. (2015). Amorphastilbol exerts beneficial effects on glucose and lipid metabolism in mice consuming a high-fat-diet. International Journal of Molecular Medicine, 36, 527-533. https://doi.org/10.3892/ijmm.2015.2227
MLA
Lee, W., Ham, J., Kwon, H. C., Yoon, G., Bae, G., Kim, Y. K., Kim, S."Amorphastilbol exerts beneficial effects on glucose and lipid metabolism in mice consuming a high-fat-diet". International Journal of Molecular Medicine 36.2 (2015): 527-533.
Chicago
Lee, W., Ham, J., Kwon, H. C., Yoon, G., Bae, G., Kim, Y. K., Kim, S."Amorphastilbol exerts beneficial effects on glucose and lipid metabolism in mice consuming a high-fat-diet". International Journal of Molecular Medicine 36, no. 2 (2015): 527-533. https://doi.org/10.3892/ijmm.2015.2227