Leptin expression in colorectal and breast cancer patients.

  • Authors: L Tessitore, B Vizio, O Jenkins, I De Stefano, C Ritossa, J M Argiles, C Benedetto, A Mussa
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  • Published online on: Saturday, April 1, 2000
  • Pages: 421-427
  • DOI: 10.3892/ijmm.5.4.421

Abstract

Leptin is a hormone which controls fat metabolism. Leptin plasma levels and adipose tissue mRNA expression were measured in cancer patients. Plasma levels were correlated with TNM staging, cachexia parameters, tumour markers and hormones. Breast and colorectal cancer patients showed blood plasma levels of insulin, TNF-alpha and tumour markers higher than controls. Breast cancer patients, but not colorectal cancer patients, had plasma levels and adipose tissue expression of leptin significantly higher than controls associated with elevated values of estrogen- and progesterone-receptors. These data suggest the possible use of leptin as a clinical marker.
Journal Cover

April 2000
Volume 5 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

2012 Impact Factor: 1.957
Ranked #26/121 Medicine Research and Experimental
(total number of cites)

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APA
Tessitore, L., Vizio, B., Jenkins, O., De Stefano, I., Ritossa, C., Argiles, J., Benedetto, C., & Mussa, A. (2000). Leptin expression in colorectal and breast cancer patients.. International Journal of Molecular Medicine, 5(4), 421-427.
MLA
Tessitore, Vizio, Jenkins, De Stefano, Ritossa, Argiles, Benedetto, and A Mussa. "Leptin expression in colorectal and breast cancer patients.." International Journal of Molecular Medicine International Journal of Molecular Medicine 5.4 (2000): 421-427.
Chicago
Tessitore, Vizio, Jenkins, De Stefano, Ritossa, Argiles, Benedetto, and A Mussa. "Leptin expression in colorectal and breast cancer patients.." International Journal of Molecular Medicine International Journal of Molecular Medicine 5 no. 4 (2000): 421-427.