Signaling pathways induced by vascular endothelial growth factor (review).

  • Authors: B Larrivée, A Karsan
  • View Affiliations

  • Published online on: Monday, May 1, 2000
  • Pages: 447-503
  • DOI: 10.3892/ijmm.5.5.447

Abstract

Vasculogenesis and angiogenesis are the mechanisms responsible for the development of the blood vessels. Angiogenesis refers to the formation of capillaries from pre-existing vessels in the embryo and adult organism, while vasculogenesis is the development of new blood vessels from the differentiation of endothelial precursors (angioblasts) in situ. Vascular endothelial growth factor (VEGF) family members are major mediators of vasculogenesis and angiogenesis both during development and in pathological conditions. VEGF has a variety of effects on vascular endothelium, including the ability to promote endothelial cell viability, mitogenesis, chemotaxis, and vascular permeability. It mediates its activity mainly via two tyrosine kinase receptors, VEGFR-1 (flt-1) and VEGFR-2 (flk-1/KDR), although other receptors, such as neuropilin-1 and -2, can also bind VEGF. Another tyrosine kinase receptor, VEGFR-3 (flt-4) binds VEGF-C and VEGF-D and is more important in the development of lymphatic vessels. While the functional effects of VEGF on endothelial cells has been well studied, not as much is known about VEGF signaling. This review summarizes the different pathways known to be involved in VEGF signal transduction and the biological responses triggered by the VEGF signaling cascade.
Journal Cover

May 2000
Volume 5 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

2012 Impact Factor: 1.957
Ranked #26/121 Medicine Research and Experimental
(total number of cites)

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APA
Larrivée, B., & Karsan, A. (2000). Signaling pathways induced by vascular endothelial growth factor (review).. International Journal of Molecular Medicine, 5(5), 447-503.
MLA
Larrivée, and A Karsan. "Signaling pathways induced by vascular endothelial growth factor (review).." International Journal of Molecular Medicine International Journal of Molecular Medicine 5.5 (2000): 447-503.
Chicago
Larrivée, and A Karsan. "Signaling pathways induced by vascular endothelial growth factor (review).." International Journal of Molecular Medicine International Journal of Molecular Medicine 5 no. 5 (2000): 447-503.