Free DNA induces modification on the protein synthesis profile of human peripheral blood mononuclear cells of healthy donors.

  • Authors: G A Martins, C R Gattas, M G da Costa Carvalho
  • View Affiliations

  • Published online on: Monday, May 1, 2000
  • Pages: 511-514
  • DOI: 10.3892/ijmm.5.5.511

Abstract

Understanding how free DNA might act as a signal between cells is important for knowing how DNA orchestrates immune responses and for optimizing the therapeutic of cancer, infection and immunologic diseases. This communication demonstrates that DNAs from different origins (bacteria, T. cruzi, HeLa cells) and synthetic oligonucleotide containing an unmethylated CpG motif are capable of inducing alterations in the protein profile of normal human leukocytes. As far as we know there have been no similar studies regarding the comparative effects of different free DNAs on early protein synthesis of human peripheral blood mononuclear cells.
Journal Cover

May 2000
Volume 5 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

2013 Impact Factor: 1.88
Ranked #27/122 Medicine Research and Experimental
(total number of cites)

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APA
Martins, G., Gattas, C., & da Costa Carvalho, M. (2000). Free DNA induces modification on the protein synthesis profile of human peripheral blood mononuclear cells of healthy donors.. International Journal of Molecular Medicine, 5(5), 511-514.
MLA
Martins, Gattas, and M G da Costa Carvalho. "Free DNA induces modification on the protein synthesis profile of human peripheral blood mononuclear cells of healthy donors.." International Journal of Molecular Medicine International Journal of Molecular Medicine 5.5 (2000): 511-514.
Chicago
Martins, Gattas, and M G da Costa Carvalho. "Free DNA induces modification on the protein synthesis profile of human peripheral blood mononuclear cells of healthy donors.." International Journal of Molecular Medicine International Journal of Molecular Medicine 5 no. 5 (2000): 511-514.