Sesamolin from sesame seed inhibits proliferation by inducing apoptosis in human lymphoid leukemia Molt 4B cells

  • Authors:
    • Y. Miyahara
    • H. Hibasami
    • H. Katsuzaki
    • K. Imai
    • T. Komiya
  • Corresponding author:
  • View Affiliations

  • Published online on: Sunday, April 1, 2001
  • Pages: 369-371 DOI: 10.3892/ijmm.7.4.369

Abstract

The exposure of human lymphoid leukemia Molt 4B cells to sesamolin, a component of sesame seed led to both growth inhibition and the induction of apoptosis. Morphological change showing apoptotic bodies was observed in the cells treated with sesamolin. The fragmentation of DNA by sesamolin to oligonucleosomal-sized fragments that are characteristics of apoptosis was observed to be concentration- and time-dependent. These findings suggest that growth inhibition of Molt 4B cells by sesamolin results from the induction of apoptosis in the cells.
Journal Cover

April 2001
Volume 7 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

2014 Impact Factor: 2.088
Ranked #22/123 Medicine Research and Experimental
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APA
Miyahara, Y., Hibasami, H., Katsuzaki, H., Imai, K., & Komiya, T. (2001). Sesamolin from sesame seed inhibits proliferation by inducing apoptosis in human lymphoid leukemia Molt 4B cells. International Journal of Molecular Medicine, 7, 369-371. http://dx.doi.org/10.3892/ijmm.7.4.369
MLA
Miyahara, Y., Hibasami, H., Katsuzaki, H., Imai, K., Komiya, T."Sesamolin from sesame seed inhibits proliferation by inducing apoptosis in human lymphoid leukemia Molt 4B cells". International Journal of Molecular Medicine 7.4 (2001): 369-371.
Chicago
Miyahara, Y., Hibasami, H., Katsuzaki, H., Imai, K., Komiya, T."Sesamolin from sesame seed inhibits proliferation by inducing apoptosis in human lymphoid leukemia Molt 4B cells". International Journal of Molecular Medicine 7, no. 4 (2001): 369-371. http://dx.doi.org/10.3892/ijmm.7.4.369