HGF/SF modifies the interaction between its receptor c-Met, and the E-cadherin/catenin complex in prostate cancer cells

  • Authors: G. Davies, W. G. Jiang, M. D. Mason
  • View Affiliations

  • Published online on: Sunday, April 1, 2001
  • Pages: 385-388
  • DOI: 10.3892/ijmm.7.4.385

Abstract

The effect of HGF/SF on the association between the E-cadherin/catenin complex and the tyrosine kinase receptor c-Met, was examined in prostate cancer cells LNCap FGC. Stimulation by HGF/SF showed E-cadherin and β-catenin to be co-precipitated and located at areas of cell-cell contact with the HGF/SF receptor c-Met, as detected by immunoprecipitation and immunofluorescence respectively. Furthermore, continued exposure to this motogen increased the level of co-precipitations between the E-cadherin/catenin complex with c-Met, and also increased tyrosine phosphorylation of c-Met. In contrast, continued stimulation by HGF/SF decreased the level of co-localised peripheral staining and increased the level of cytoplasmic staining. In conclusion, the association between the E-cadherin/catenin complex with the HGF/SF receptor c-Met, may influence or regulate intercellular adhesion in prostate cancer following stimulation by HGF/SF.
Journal Cover

April 2001
Volume 7 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

2013 Impact Factor: 1.88
Ranked #27/122 Medicine Research and Experimental
(total number of cites)

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APA
Davies, G., Jiang, W., & Mason, M. (2001). HGF/SF modifies the interaction between its receptor c-Met, and the E-cadherin/catenin complex in prostate cancer cells. International Journal of Molecular Medicine, 7(4), 385-388.
MLA
Davies, Jiang, and M. Mason. "HGF/SF modifies the interaction between its receptor c-Met, and the E-cadherin/catenin complex in prostate cancer cells." International Journal of Molecular Medicine International Journal of Molecular Medicine 7.4 (2001): 385-388.
Chicago
Davies, Jiang, and M. Mason. "HGF/SF modifies the interaction between its receptor c-Met, and the E-cadherin/catenin complex in prostate cancer cells." International Journal of Molecular Medicine International Journal of Molecular Medicine 7 no. 4 (2001): 385-388.