Expression of multidrug resistance associated transporters (MDR1, MRP1, LRP and BCRP) in porcine oocyte

  • Authors: Yuji Takebayashi, Kentaro Nakayama, Toru Fujioka, Atsuko Kanzaki, Masato Mutho, Takafumi Uchida, Kohji Miyazaki, Masaharu Ito, Manabu Fukumoto
  • View Affiliations

  • Published online on: Sunday, April 1, 2001
  • Pages: 397-400
  • DOI: 10.3892/ijmm.7.4.397

Abstract

Transporters such as P-glycoprotein (MDR1), multidrug resistance protein 1 (MRP1), lung resistance-related protein (LRP) and breast cancer resistance protein (BCRP) are associated with multidrug resistance in various carcinoma cell lines. The expression of these molecules has been also characterized in human normal tissues. However, the expression of these molecules in oocyte is still unclear. In order to obtain more insight into the physiological role of these transporters, their expression in porcine oocyte were examined by reverse transcriptase-polymerase chain reaction. MDR1, MRP1 and LRP genes, but not BCRP gene were found to be expressed in porcine oocyte. After the subcloning and sequence analysis of MDR1, MRP1 and LRP genes, the high homology of these transporters were observed between porcine and human gene. These findings suggest that MDR1, MRP1 and LRP play an important physiological role(s) in an oocyte.
Journal Cover

April 2001
Volume 7 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

2013 Impact Factor: 1.88
Ranked #27/122 Medicine Research and Experimental
(total number of cites)

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Takebayashi, Y., Nakayama, K., Fujioka, T., Kanzaki, A., Mutho, M., Uchida, T., Miyazaki, K., Ito, M., & Fukumoto, M. (2001). Expression of multidrug resistance associated transporters (MDR1, MRP1, LRP and BCRP) in porcine oocyte. International Journal of Molecular Medicine, 7(4), 397-400.
MLA
Takebayashi, Nakayama, Fujioka, Kanzaki, Mutho, Uchida, Miyazaki, Ito, and Manabu Fukumoto. "Expression of multidrug resistance associated transporters (MDR1, MRP1, LRP and BCRP) in porcine oocyte." International Journal of Molecular Medicine International Journal of Molecular Medicine 7.4 (2001): 397-400.
Chicago
Takebayashi, Nakayama, Fujioka, Kanzaki, Mutho, Uchida, Miyazaki, Ito, and Manabu Fukumoto. "Expression of multidrug resistance associated transporters (MDR1, MRP1, LRP and BCRP) in porcine oocyte." International Journal of Molecular Medicine International Journal of Molecular Medicine 7 no. 4 (2001): 397-400.