Negative and positive transcriptional control during cell proliferation (Review)

  • Authors: L Lania, P DeLuca, B Majello
  • View Affiliations

  • Published online on: Friday, August 1, 1997
  • Pages: 359-363
  • DOI: 10.3892/ijo.11.2.359

Abstract

A significant amount of experimental evidence has demonstrated that progression of the cell cycle in mammalian cells is associated with periodic transcriptional activation/ repression of growth-regulatory genes. We summarize our current knowledge and views on the role of the critical cell cycle regulators such as the retinoblastoma proteins in transcription repression and their functional connections with various different transcription factors. In addition, we discuss the role of oncogenes such as TIF1 alpha, PML and RFL which belong to a characteristic subgroup of RING finger proteins that contain the RING finger (C3HC4 zinc finger) the B-boxes and a putative coiled-coil (RBCC configuration) as mediators of transcription repression.
Journal Cover

August 1997
Volume 11 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

2012 Impact Factor: 2.657
Ranked #31/196 Oncology
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APA
Lania, L., DeLuca, P., & Majello, B. (1997). Negative and positive transcriptional control during cell proliferation (Review). International Journal of Oncology, 11(2), 359-363.
MLA
Lania, DeLuca, and B Majello. "Negative and positive transcriptional control during cell proliferation (Review)." International Journal of Oncology International Journal of Oncology 11.2 (1997): 359-363.
Chicago
Lania, DeLuca, and B Majello. "Negative and positive transcriptional control during cell proliferation (Review)." International Journal of Oncology International Journal of Oncology 11 no. 2 (1997): 359-363.