Distinctive actions of interleukin-13 and interleukin-4 on growth of hematopoietic progenitors.

  • Authors:
    • T Sugawara
    • N Katayama
    • K Nishii
    • N Mahmud
    • H Mitani
    • K Ohishi
    • M Masuya
    • N Minami
    • H Shiku
  • Corresponding author:
  • View Affiliations

  • Published online on: Monday, March 1, 1999
  • Pages: 471-478 DOI: 10.3892/ijo.14.3.471

Abstract

We examined the effects of interleukin (IL)-13 and IL-4 on growth of hematopoietic progenitors from 5-fluorouracil (5-FU)-treated mice, using an in vitro culture system. IL-13 or IL-4 alone failed to support colony formation by enriched marrow cells. IL-4 but not IL-13 in combination with IL-11 yielded a significant number of colonies. Neither IL-4 nor IL-13 affected colony formation supported by IL-3. When tested with two-factor combinations, IL-4 but not IL-13 suppressed the formation of colonies including multilineage colonies in the absence of IL-11. The inhibitory effects of IL-4 were not lineage-specific. Delayed addition experiments demonstrated that IL-4 is inhibitory in the early stage of colony formation. Effects of IL-4 on colony formation by pooled blast cells derived from 5-day culture of post-5-FU marrow cells was not evident. These findings indicate that IL-4 but not IL-13 is a negative regulator of hematopoietic progenitors, suggesting distinctive roles for IL-4 and IL-13 in early hematopoiesis.
Journal Cover

March 1999
Volume 14 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

2013 Impact Factor: 2.773
2014 I.F. (Expected) ≥ 3.258 Ranked #30/202 Oncology
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APA
Sugawara, T., Katayama, N., Nishii, K., Mahmud, N., Mitani, H., Ohishi, K. ... Shiku, H. (1999). Distinctive actions of interleukin-13 and interleukin-4 on growth of hematopoietic progenitors.. International Journal of Oncology, 14, 471-478. http://dx.doi.org/10.3892/ijo.14.3.471
MLA
Sugawara, T., Katayama, N., Nishii, K., Mahmud, N., Mitani, H., Ohishi, K., Masuya, M., Minami, N., Shiku, H."Distinctive actions of interleukin-13 and interleukin-4 on growth of hematopoietic progenitors.". International Journal of Oncology 14.3 (1999): 471-478.
Chicago
Sugawara, T., Katayama, N., Nishii, K., Mahmud, N., Mitani, H., Ohishi, K., Masuya, M., Minami, N., Shiku, H."Distinctive actions of interleukin-13 and interleukin-4 on growth of hematopoietic progenitors.". International Journal of Oncology 14, no. 3 (1999): 471-478. http://dx.doi.org/10.3892/ijo.14.3.471