Distinctive actions of interleukin-13 and interleukin-4 on growth of hematopoietic progenitors.

  • Authors: T Sugawara, N Katayama, K Nishii, N Mahmud, H Mitani, K Ohishi, M Masuya, N Minami, H Shiku
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  • Published online on: Monday, March 1, 1999
  • Pages: 471-478
  • DOI: 10.3892/ijo.14.3.471

Abstract

We examined the effects of interleukin (IL)-13 and IL-4 on growth of hematopoietic progenitors from 5-fluorouracil (5-FU)-treated mice, using an in vitro culture system. IL-13 or IL-4 alone failed to support colony formation by enriched marrow cells. IL-4 but not IL-13 in combination with IL-11 yielded a significant number of colonies. Neither IL-4 nor IL-13 affected colony formation supported by IL-3. When tested with two-factor combinations, IL-4 but not IL-13 suppressed the formation of colonies including multilineage colonies in the absence of IL-11. The inhibitory effects of IL-4 were not lineage-specific. Delayed addition experiments demonstrated that IL-4 is inhibitory in the early stage of colony formation. Effects of IL-4 on colony formation by pooled blast cells derived from 5-day culture of post-5-FU marrow cells was not evident. These findings indicate that IL-4 but not IL-13 is a negative regulator of hematopoietic progenitors, suggesting distinctive roles for IL-4 and IL-13 in early hematopoiesis.
Journal Cover

March 1999
Volume 14 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

2012 Impact Factor: 2.773
Ranked #30/202 Oncology
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APA
Sugawara, T., Katayama, N., Nishii, K., Mahmud, N., Mitani, H., Ohishi, K., Masuya, M., Minami, N., & Shiku, H. (1999). Distinctive actions of interleukin-13 and interleukin-4 on growth of hematopoietic progenitors.. International Journal of Oncology, 14(3), 471-478.
MLA
Sugawara, Katayama, Nishii, Mahmud, Mitani, Ohishi, Masuya, Minami, and H Shiku. "Distinctive actions of interleukin-13 and interleukin-4 on growth of hematopoietic progenitors.." International Journal of Oncology International Journal of Oncology 14.3 (1999): 471-478.
Chicago
Sugawara, Katayama, Nishii, Mahmud, Mitani, Ohishi, Masuya, Minami, and H Shiku. "Distinctive actions of interleukin-13 and interleukin-4 on growth of hematopoietic progenitors.." International Journal of Oncology International Journal of Oncology 14 no. 3 (1999): 471-478.