Clinicopathological and genetic characteristics of mucinous carcinomas in the colorectum.

  • Authors:
    • H Zhang
    • S Evertsson
    • X Sun
  • View Affiliations

  • Published online on: Tuesday, June 1, 1999
  • Pages: 1057-1118
  • DOI: 10.3892/ijo.14.6.1057

Abstract

We investigated the clinicopathological and genetic characteristics including patients' gender, age, tumour location, growth pattern, Dukes' stage, DNA ploidy, S-phase fraction, PCNA, apoptosis, c-erbB-2, bcl-2, K-ras, p53, DCC and heat shock protein in 32 mucinous carcinomas versus 261 non-mucinous carcinomas in the colorectum. Sixty percent of mucinous carcinomas were located in the right colon, 13% in the left colon and 27% in the rectum (p=0.01). More mucinous carcinomas grew in expanding pattern than non-mucinous carcinomas (66% vs 39%, p=0.005). Compared with non-mucinous carcinoma, mucinous carcinoma had more K-ras mutations (50% vs 25%, p=0.02), but less p53 expression (72% vs 49%, p=0.02) and less apoptotic activity (19% vs 51%, p=0.01). We further confirm that the mucinous carcinoma in the colorectum represents a distinct clinicopathologic and genetic features as compared to non-mucinous tumour, and may have a different biological behaviour.
Journal Cover

June 1999
Volume 14 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

2013 Impact Factor: 2.773
Ranked #30/202 Oncology
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APA
Zhang, H., Evertsson, S., & Sun, X. (1999). Clinicopathological and genetic characteristics of mucinous carcinomas in the colorectum.. International Journal of Oncology, 14(6), 1057-1118.
MLA
Zhang, Evertsson, and X Sun. "Clinicopathological and genetic characteristics of mucinous carcinomas in the colorectum.." International Journal of Oncology International Journal of Oncology 14.6 (1999): 1057-1118.
Chicago
Zhang, Evertsson, and X Sun. "Clinicopathological and genetic characteristics of mucinous carcinomas in the colorectum.." International Journal of Oncology International Journal of Oncology 14 no. 6 (1999): 1057-1118.