Involvement of galectin-3 expression in colorectal cancer progression and metastasis.

  • Authors: M Nakamura, H Inufusa, T Adachi, M Aga, M Kurimoto, Y Nakatani, T Wakano, A Nakajima, J I Hida, M Miyake, K Shindo, M Yasutomi
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  • Published online on: Thursday, July 1, 1999
  • Pages: 143-151
  • DOI: 10.3892/ijo.15.1.143

Abstract

Galectin-3 is a beta-galactoside-specific lectin that binds to laminin sugar-sites and is involved in tumor malignancy. Galectin-3 expression in relation to primary tumor and liver metastasis of colorectal cancer was examined to determined its involvement in cancer progression and metastasis. Immunohistochemical staining of galectin-3 was performed on 117 primary lesions and 15 liver metastases of colorectal cancer using TIB166 monoclonal antibody. The expression of galectin-3 was evaluated by grading the intensity of the staining as either negative, weakly positive, or strongly positive. Normal mucosa of all patients were strongly positive for galectin-3, but the staining in these tissues was still significantly less than in the primary lesions of the cancer (31.6%). Galectin-3 expression in the primary lesions was significantly increased, correlating with the progression of clinical stage (p=0. 0224), liver metastasis (p<0.0001), venous invasion (p=0.0048), and lymph node metastasis (p=0.0289). Liver metastatic lesions also showed up-regulated levels of galectin-3 compared to the primary lesions (p=0.0030). The group showing strongly positive galectin-3 had a significantly poorer prognosis than the negative/weakly positive group in terms of disease-free survival (p=0.0224). The strong expression of galectin-3 in colorectal cancer correlates with cancer progression, liver metastasis, and poor prognosis for patients.
Journal Cover

July 1999
Volume 15 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

2012 Impact Factor: 2.657
Ranked #31/196 Oncology
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APA
Nakamura, M., Inufusa, H., Adachi, T., Aga, M., Kurimoto, M., Nakatani, Y., Wakano, T., Nakajima, A., Hida, J., Miyake, M., Shindo, K., & Yasutomi, M. (1999). Involvement of galectin-3 expression in colorectal cancer progression and metastasis.. International Journal of Oncology, 15(1), 143-151.
MLA
Nakamura, Inufusa, Adachi, Aga, Kurimoto, Nakatani, Wakano, Nakajima, Hida, Miyake, Shindo, and M Yasutomi. "Involvement of galectin-3 expression in colorectal cancer progression and metastasis.." International Journal of Oncology International Journal of Oncology 15.1 (1999): 143-151.
Chicago
Nakamura, Inufusa, Adachi, Aga, Kurimoto, Nakatani, Wakano, Nakajima, Hida, Miyake, Shindo, and M Yasutomi. "Involvement of galectin-3 expression in colorectal cancer progression and metastasis.." International Journal of Oncology International Journal of Oncology 15 no. 1 (1999): 143-151.