Involvement of the Ink4a gene (p16 and p19arf) in murine tumorigenesis.

  • Authors:
    • I Orlow
    • F Rabbani
    • L Chin
    • J Pomerantz
    • N Ligeois
    • M Dudas
    • R Depinho
    • C Cordón-Cardó
  • View Affiliations

  • Published online on: Thursday, July 1, 1999
  • Pages: 17-41
  • DOI: 10.3892/ijo.15.1.17

Abstract

The INK4A and INK4B genes map to 9p21, with the INK4A gene encoding two products, p16 and p19ARF. Many neoplasms in which INK4A and INK4B genes are altered show deletions involving both genes. Mice carrying a targeted Ink4a deletion develop tumors at an early age. In the present study we examined the genetic alterations affecting the remaining Ink4a allele and the Ink4b gene in tumors arising in heterozygous Ink4a mice. We identified deletion of the remaining Ink4a allele in 7 of 18 (39%) tumors. We also observed deletion of the exon 1beta in 3 cases, one of them presenting this deletion as a unique alteration. In conclusion, the deletion of the remaining Ink4a allele was the alteration most frequently observed, representing the inactivation of two proteins capable of arresting the cell cycle through different pathways that involve the tumor suppressors pRB and p53.
Journal Cover

July 1999
Volume 15 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

2013 Impact Factor: 2.773
Ranked #30/202 Oncology
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APA
Orlow, I., Rabbani, F., Chin, L., Pomerantz, J., Ligeois, N., Dudas, M., Depinho, R., & Cordón-Cardó, C. (1999). Involvement of the Ink4a gene (p16 and p19arf) in murine tumorigenesis.. International Journal of Oncology, 15(1), 17-41.
MLA
Orlow, Rabbani, Chin, Pomerantz, Ligeois, Dudas, Depinho, and C Cordón-Cardó. "Involvement of the Ink4a gene (p16 and p19arf) in murine tumorigenesis.." International Journal of Oncology International Journal of Oncology 15.1 (1999): 17-41.
Chicago
Orlow, Rabbani, Chin, Pomerantz, Ligeois, Dudas, Depinho, and C Cordón-Cardó. "Involvement of the Ink4a gene (p16 and p19arf) in murine tumorigenesis.." International Journal of Oncology International Journal of Oncology 15 no. 1 (1999): 17-41.