The transcriptional function of the hepatitis B virus X protein and its role in hepatocarcinogenesis (Review).

  • Authors:
    • O M Andrisani
    • S Barnabas
  • View Affiliations

  • Published online on: Sunday, August 1, 1999
  • Pages: 373-382
  • DOI: 10.3892/ijo.15.2.373

Abstract

The hepatitis B virus (HBV) encodes a 16.5 kDa multifunctional protein termed pX or HBx, required for transcription of the viral genome and implicated in the development of hepatocellular carcinoma (HCC) in chronic HBV-infected patients. However, the mechanism of pX-mediated hepatocarcinogenesis remains unknown. pX is a multifunctional protein exhibiting a number of activities affecting transcription, cell growth, and apoptotic cell death. Although pX does not directly bind DNA, pX is regarded as a promiscuous transactivator, acting via a dual mechanism: in the cytoplasm, pX activates mitogenic signaling cascades; in the nucleus, pX interacts directly with members of the bZip class of transcription factors and with specific components of the basal transcriptional apparatus. The focus of this review is to describe the transactivation function of pX and its role in hepatocarcinogenesis.
Journal Cover

August 1999
Volume 15 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

2013 Impact Factor: 2.773
Ranked #30/202 Oncology
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APA
Andrisani, O., & Barnabas, S. (1999). The transcriptional function of the hepatitis B virus X protein and its role in hepatocarcinogenesis (Review).. International Journal of Oncology, 15(2), 373-382.
MLA
Andrisani, and S Barnabas. "The transcriptional function of the hepatitis B virus X protein and its role in hepatocarcinogenesis (Review).." International Journal of Oncology International Journal of Oncology 15.2 (1999): 373-382.
Chicago
Andrisani, and S Barnabas. "The transcriptional function of the hepatitis B virus X protein and its role in hepatocarcinogenesis (Review).." International Journal of Oncology International Journal of Oncology 15 no. 2 (1999): 373-382.