Angiogenesis is prognostically important in vertical growth phase melanomas.

  • Authors:
    • O Straume
    • H B Salvesen
    • L A Akslen
  • View Affiliations

  • Published online on: September 1, 1999     https://doi.org/10.3892/ijo.15.3.595
  • Pages: 595-604
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Abstract

The association between microvessel density (MVD) and patient survival has recently been established for various types of human cancers. Immunohistochemical staining (factor-VIII related antigen) was performed on a series of 102 vertical growth phase melanomas and vessels were counted in areas. Increased MVD was associated with large histologic tumor diameter (p=0.006) and tumor ulceration (p=0.04). Further, high vascular density was significantly related to decreased patient survival (p=0.04), with borderline significance (p=0.10) in the final multivariate model. The results of this study suggest that microvessel density is of prognostic importance in aggressive vertical growth phase melanomas.

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Sep 1999
Volume 15 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Straume O, Salvesen H and Akslen L: Angiogenesis is prognostically important in vertical growth phase melanomas.. Int J Oncol 15: 595-604, 1999.
APA
Straume, O., Salvesen, H., & Akslen, L. (1999). Angiogenesis is prognostically important in vertical growth phase melanomas.. International Journal of Oncology, 15, 595-604. https://doi.org/10.3892/ijo.15.3.595
MLA
Straume, O., Salvesen, H., Akslen, L."Angiogenesis is prognostically important in vertical growth phase melanomas.". International Journal of Oncology 15.3 (1999): 595-604.
Chicago
Straume, O., Salvesen, H., Akslen, L."Angiogenesis is prognostically important in vertical growth phase melanomas.". International Journal of Oncology 15, no. 3 (1999): 595-604. https://doi.org/10.3892/ijo.15.3.595