Neuropilin-2 expression affects the increased vascularization and is a prognostic factor in osteosarcoma.

  • Authors: A Handa, T Tokunaga, T Tsuchida, Y H Lee, H Kijima, H Yamazaki, Y Ueyama, H Fukuda, M Nakamura
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  • Published online on: Tuesday, August 1, 2000
  • Pages: 291-296
  • DOI: 10.3892/ijo.17.2.291

Abstract

Osteosarcoma is a malignant bone tumor characterized by hypervascularity. Neuropilins (NRPs), which is expressed by human tumor cells, is known to be a potent receptor for vascular endothelial growth factor (VEGF). We examined NRPs mRNA expression in 30 osteosarcomas. The osteosarcomas with NRP2 expression (n=24) showed a significantly increased vascularity (P<0.0014, Mann-Whitney U test). Osteosarcomas with NRP2 showed significantly poorer prognosis than those without NRP2 (P=0.016, Wilcoxon's test). These results suggest that NRP acts as a VEGF-amplifier in a paracrine or autocrine manner in the osteosarcoma. NRP2 expression cooperatively promotes angiogenesis and growth in osteosarcomas with VEGF expression.
Journal Cover

August 2000
Volume 17 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

2013 Impact Factor: 2.773
Ranked #30/202 Oncology
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APA
Handa, A., Tokunaga, T., Tsuchida, T., Lee, Y., Kijima, H., Yamazaki, H., Ueyama, Y., Fukuda, H., & Nakamura, M. (2000). Neuropilin-2 expression affects the increased vascularization and is a prognostic factor in osteosarcoma.. International Journal of Oncology, 17(2), 291-296.
MLA
Handa, Tokunaga, Tsuchida, Lee, Kijima, Yamazaki, Ueyama, Fukuda, and M Nakamura. "Neuropilin-2 expression affects the increased vascularization and is a prognostic factor in osteosarcoma.." International Journal of Oncology International Journal of Oncology 17.2 (2000): 291-296.
Chicago
Handa, Tokunaga, Tsuchida, Lee, Kijima, Yamazaki, Ueyama, Fukuda, and M Nakamura. "Neuropilin-2 expression affects the increased vascularization and is a prognostic factor in osteosarcoma.." International Journal of Oncology International Journal of Oncology 17 no. 2 (2000): 291-296.