C-Cbl protein in human cancer tissues is frequently tyrosine phosphorylated in a tumor-specific manner.

  • Authors: T Kamei, K Machida, Y Nimura, T Senga, I Yamada, S Yoshii, S Matsuda, M Hamaguchi
  • View Affiliations

  • Published online on: Tuesday, August 1, 2000
  • Pages: 335-344
  • DOI: 10.3892/ijo.17.2.335

Abstract

To search for the signaling pathway relevant to the tumorigenesis in human, we examined the expression and tyrosine phosphorylation of c-cbl proto-oncogene product, c-Cbl, in various human cancer cell lines and surgical specimens. In cells derived from human cancer, we found constitutive tyrosine phosphorylation of c-Cbl protein, whereas its phosphorylation was undetectable in control ECV304 cells. Expression and tyrosine phosphorylation of c-Cbl was also examined in various surgical specimens. Thirty-six surgical specimens obtained from human tumor tissues were studied: 9 gastric carcinomas, 10 colon carcinomas, 6 renal carcinomas, 2 hepatomas, 2 brain tumors, 2 uterus tumors, 1 breast carcinoma, 1 thyroid tumor, 1 bladder tumor and 2 lung carcinomas. We found tyrosine phosphorylation of c-Cbl protein in 12 cases (33%) of these tumor tissues in a tumor-specific manner. These results suggest the importance of c-Cbl signaling in tumorigenesis in human.
Journal Cover

August 2000
Volume 17 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

2012 Impact Factor: 2.657
Ranked #31/196 Oncology
(total number of cites)

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Kamei, T., Machida, K., Nimura, Y., Senga, T., Yamada, I., Yoshii, S., Matsuda, S., & Hamaguchi, M. (2000). C-Cbl protein in human cancer tissues is frequently tyrosine phosphorylated in a tumor-specific manner.. International Journal of Oncology, 17(2), 335-344.
MLA
Kamei, Machida, Nimura, Senga, Yamada, Yoshii, Matsuda, and M Hamaguchi. "C-Cbl protein in human cancer tissues is frequently tyrosine phosphorylated in a tumor-specific manner.." International Journal of Oncology International Journal of Oncology 17.2 (2000): 335-344.
Chicago
Kamei, Machida, Nimura, Senga, Yamada, Yoshii, Matsuda, and M Hamaguchi. "C-Cbl protein in human cancer tissues is frequently tyrosine phosphorylated in a tumor-specific manner.." International Journal of Oncology International Journal of Oncology 17 no. 2 (2000): 335-344.