Modulation of cell cycle regulatory protein expression and suppression of tumor growth by mimosine in nude mice.

  • Authors:
    • H C Chang
    • C F Weng
    • M H Yen
    • L Y Chuang
    • W C Hung
  • View Affiliations

  • Published online on: Sunday, October 1, 2000
  • Pages: 659-724
  • DOI: 10.3892/ijo.17.4.659

Abstract

Our previous results demonstrated that the plant amino acid mimosine blocked cell cycle progression and suppressed proliferation of human lung cancer cells in vitro by multiple mechanisms. Inhibition of cyclin D1 expression or induction of cyclin-dependent kinase inhibitor p21WAF1 expression was found in mimosine-treated lung cancer cells. However, whether mimosine may modulate the expression of these cell cycle regulatory proteins and suppress tumor growth in vivo is unknown. In this study, we examined the anti-cancer effect of mimosine on human H226 lung cancer cells grown in nude mice. Our results demonstrated that mimosine inhibits cyclin D1 and induces p21WAF1 expression in vivo. Furthermore, results of TUNEL analysis indicated that mimosine may induce apoptosis to suppress tumor growth in nude mice. Collectively, these results suggest that mimosine exerts anti-cancer effect in vivo and might be useful in the therapy of lung cancer.
Journal Cover

October 2000
Volume 17 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

2013 Impact Factor: 2.773
Ranked #30/202 Oncology
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APA
Chang, H., Weng, C., Yen, M., Chuang, L., & Hung, W. (2000). Modulation of cell cycle regulatory protein expression and suppression of tumor growth by mimosine in nude mice.. International Journal of Oncology, 17(4), 659-724.
MLA
Chang, Weng, Yen, Chuang, and W C Hung. "Modulation of cell cycle regulatory protein expression and suppression of tumor growth by mimosine in nude mice.." International Journal of Oncology International Journal of Oncology 17.4 (2000): 659-724.
Chicago
Chang, Weng, Yen, Chuang, and W C Hung. "Modulation of cell cycle regulatory protein expression and suppression of tumor growth by mimosine in nude mice.." International Journal of Oncology International Journal of Oncology 17 no. 4 (2000): 659-724.