Molecular analysis of the h-warts/LATS1 gene in human breast cancer.

  • Authors: N Morinaga, Y Shitara, Y Yanagita, T Koida, M Kimura, T Asao, I Kimijima, S Takenoshita, T Hirota, H Saya, H Kuwano
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  • Published online on: Friday, December 1, 2000
  • Pages: 1125-1134
  • DOI: 10.3892/ijo.17.6.1125

Abstract

Loss of heterozygosity (LOH) on chromosome 6q is often observed in breast cancer, suggesting the existence of a putative tumor suppressor. Recently, a human homolog of the Drosophila warts tumor suppressor gene, h-warts/LATS1, was identified and mapped at chromosome 6q24-25.1. Mutation analysis of the h-warts/LATS1 was performed using 25 breast cancer tissues by RT-PCR SSCP analysis. Although LOH of the h-warts/LATS1 was found in one patient, no mutations were found. Two polymorphisms were found, but neither of them caused amino acid substitutions. Further investigations are necessary to elucidate the role of the h-warts/LATS1 gene in the carcinogenesis of breast cancer.
Journal Cover

December 2000
Volume 17 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

2012 Impact Factor: 2.657
Ranked #31/196 Oncology
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APA
Morinaga, N., Shitara, Y., Yanagita, Y., Koida, T., Kimura, M., Asao, T., Kimijima, I., Takenoshita, S., Hirota, T., Saya, H., & Kuwano, H. (2000). Molecular analysis of the h-warts/LATS1 gene in human breast cancer.. International Journal of Oncology, 17(6), 1125-1134.
MLA
Morinaga, Shitara, Yanagita, Koida, Kimura, Asao, Kimijima, Takenoshita, Hirota, Saya, and H Kuwano. "Molecular analysis of the h-warts/LATS1 gene in human breast cancer.." International Journal of Oncology International Journal of Oncology 17.6 (2000): 1125-1134.
Chicago
Morinaga, Shitara, Yanagita, Koida, Kimura, Asao, Kimijima, Takenoshita, Hirota, Saya, and H Kuwano. "Molecular analysis of the h-warts/LATS1 gene in human breast cancer.." International Journal of Oncology International Journal of Oncology 17 no. 6 (2000): 1125-1134.