TUMOR-CYTOTOXICITY OF NITRIC-OXIDE PRODUCED FROM ALVEOLAR MACROPHAGES DIRECTLY STIMULATED WITH TUMOR-CELLS

  • Authors: Y NOZAKI, KI ISOBE, I NAKASHIMA, K SHIMOKATA
  • View Affiliations

  • Published online on: Tuesday, June 1, 1993
  • Pages: 1053-1057
  • DOI: 10.3892/ijo.2.6.1053

Abstract

Macrophages activated by lipopolysaccharide or interferon-gamma have been shown to be cytotoxic to tumor cells by releasing nitric oxide. Here, we report that unstimulated rat alveolar macrophages cultured with certain tumor cells produce nitric oxide and are cytotoxic to these tumor cells. Alveolar macrophages were taken from BUF/Mna rats, which were known to produce spontaneous thymoma, and cultured with syngeneic BUF/Mna-derived thymoma cells. They were killed by syngeneic or allogeneic alveolar macrophages and this killing was partially abolished by addition of N(G)-monomethyl-L-arginine. X-ray irradiated, mitomycin C-treated or membranous fragments of BUF/Mna-derived thymoma cells directly stimulated rat alveolar macrophages to produce nitric oxide.
Journal Cover

June 1993
Volume 2 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

2012 Impact Factor: 2.773
Ranked #30/202 Oncology
(total number of cites)

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
NOZAKI, Y., ISOBE, K., NAKASHIMA, I., & SHIMOKATA, K. (1993). TUMOR-CYTOTOXICITY OF NITRIC-OXIDE PRODUCED FROM ALVEOLAR MACROPHAGES DIRECTLY STIMULATED WITH TUMOR-CELLS. International Journal of Oncology, 2(6), 1053-1057.
MLA
NOZAKI, ISOBE, NAKASHIMA, and K SHIMOKATA. "TUMOR-CYTOTOXICITY OF NITRIC-OXIDE PRODUCED FROM ALVEOLAR MACROPHAGES DIRECTLY STIMULATED WITH TUMOR-CELLS." International Journal of Oncology International Journal of Oncology 2.6 (1993): 1053-1057.
Chicago
NOZAKI, ISOBE, NAKASHIMA, and K SHIMOKATA. "TUMOR-CYTOTOXICITY OF NITRIC-OXIDE PRODUCED FROM ALVEOLAR MACROPHAGES DIRECTLY STIMULATED WITH TUMOR-CELLS." International Journal of Oncology International Journal of Oncology 2 no. 6 (1993): 1053-1057.