EXPRESSION OF PS2 AND CATHEPSIN-D IN BREAST-CANCER

  • Authors: JL CAZIN, P GOSSELIN, B BONIFACE, M BONIFACE, A DEMAILLE
  • View Affiliations

  • Published online on: Tuesday, June 1, 1993
  • Pages: 1081-1084
  • DOI: 10.3892/ijo.2.6.1081

Abstract

Cytosolic levels of pS2 and Cathepsin D (Cath D) were compared in 145 primary breast cancer patients using the immunoradiometric (IRMA) assays ELSA-pS2-degrees and ELSA-Cath. D-degrees of Cis biointernational. The mean values were 20.04 +/- 41.75 ng pS2/mg of cytosol protein (cp) and 49.94 +/- 33.71 pmol Cath D/mg cp. The pS2 level was significantly associated with Estrogen Receptor (ER), Progesterone Receptor (PgR) and Cath D levels. Significant associations were also found between Log (pS2) or Log (Cath. D) and differentiation grade (SBR), between Log (pS2) and ER (+,-) or PgR (+,-), between Log (Cath. D) and PgR (+,-). No correlations were noted between Log (pS2) or Log (Cath D) and menopausal status, tumor size (T) and lymph node involvement (N), between pS2 and age, between Cath D and age, ER and PgR, between Log (Cath D) and ER (+,-). Contrary to Cath D, pS2 was strongly linked to steroid receptors.
Journal Cover

June 1993
Volume 2 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

2013 Impact Factor: 2.773
Ranked #30/202 Oncology
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APA
CAZIN, J., GOSSELIN, P., BONIFACE, B., BONIFACE, M., & DEMAILLE, A. (1993). EXPRESSION OF PS2 AND CATHEPSIN-D IN BREAST-CANCER. International Journal of Oncology, 2(6), 1081-1084.
MLA
CAZIN, GOSSELIN, BONIFACE, BONIFACE, and A DEMAILLE. "EXPRESSION OF PS2 AND CATHEPSIN-D IN BREAST-CANCER." International Journal of Oncology International Journal of Oncology 2.6 (1993): 1081-1084.
Chicago
CAZIN, GOSSELIN, BONIFACE, BONIFACE, and A DEMAILLE. "EXPRESSION OF PS2 AND CATHEPSIN-D IN BREAST-CANCER." International Journal of Oncology International Journal of Oncology 2 no. 6 (1993): 1081-1084.