Adverse effects of obesity on breast cancer prognosis, and the biological actions of leptin (Review)

  • Authors: David P. Rose, Elaine M. Gilhooly, Daniel W. Nixon
  • View Affiliations

  • Published online on: Sunday, December 1, 2002
  • Pages: 1285-1292
  • DOI: 10.3892/ijo.21.6.1285

Abstract

Leptin is a hormone with multiple biological actions which is produced predominantly by adipose tissue; in humans, plasma levels correlate with total body fat, and particularly high concentrations occur in obese women. Several actions of leptin, including the stimulation of normal and tumor cell growth, migration and invasion, and enhancement of angiogenesis, suggest that this hormone can promote an aggressive breast cancer phenotype which can be estrogen-independent. This effect may involve activation of the transcription factor NFκB. Leptin can also induce aromatase activity, with the potential for the promotion of estrogen production from androstenedione in adipose tissue, and hence the stimulation of estrogen-dependent breast cancer progression. On this basis, we hypothesize that leptin, perhaps in association with insulin, the plasma concentrations of which correlate with those of leptin, has an important role in the known adverse effect of obesity on breast cancer.
Journal Cover

December 2002
Volume 21 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

2013 Impact Factor: 2.773
Ranked #30/202 Oncology
(total number of cites)

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APA
Rose, D., Gilhooly, E., & Nixon, D. (2002). Adverse effects of obesity on breast cancer prognosis, and the biological actions of leptin (Review). International Journal of Oncology, 21(6), 1285-1292.
MLA
Rose, Gilhooly, and Daniel Nixon. "Adverse effects of obesity on breast cancer prognosis, and the biological actions of leptin (Review)." International Journal of Oncology International Journal of Oncology 21.6 (2002): 1285-1292.
Chicago
Rose, Gilhooly, and Daniel Nixon. "Adverse effects of obesity on breast cancer prognosis, and the biological actions of leptin (Review)." International Journal of Oncology International Journal of Oncology 21 no. 6 (2002): 1285-1292.