Identification of a novel human gene, ZFP91, involved in acute myelogenous leukemia

  • Authors:
    • Motoko Unoki
    • Junichi Okutsu
    • Yusuke Nakamura
  • View Affiliations

  • Published online on: June 1, 2003     https://doi.org/10.3892/ijo.22.6.1217
  • Pages: 1217-1223
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

To elucidate mechanisms leading to acute myelogenous leukemia (AML), to find sensitive markers and novel targets for drug therapy, and to allow choice of suitable chemotherapy for each affected individual, we previously compared expression of mRNA from mononuclear cells of AML patients with that of normal controls using a cDNA microarray. Data from that study identified many genes that were commonly up- or down-regulated in AML cells. Of these, we report here the identification of a novel gene whose expression was increased in 27 (93%) of the 29 AML cases whose PBMC preparations include >70% leukemia cells. The gene product, localized in nuclei, showed several characteristics of transcription factors: five zinc-finger domains, a leucine zipper, and several nuclear localization signals. Its 92.5% identity in amino-acid sequence to the murine penta zinc finger protein (mPZf; gene symbol Zfp91), led us to term it ZFP91. Anti-sense oligonucleotides inhibited expression of ZFP91, suppressed cell growth, and induced apoptosis. Our results suggest that ZFP91 is likely to play an important role in cell proliferation and/or anti-apoptosis, and may serve as a molecular marker for AML.

Related Articles

Journal Cover

June 2003
Volume 22 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Unoki M, Okutsu J and Nakamura Y: Identification of a novel human gene, ZFP91, involved in acute myelogenous leukemia. Int J Oncol 22: 1217-1223, 2003.
APA
Unoki, M., Okutsu, J., & Nakamura, Y. (2003). Identification of a novel human gene, ZFP91, involved in acute myelogenous leukemia. International Journal of Oncology, 22, 1217-1223. https://doi.org/10.3892/ijo.22.6.1217
MLA
Unoki, M., Okutsu, J., Nakamura, Y."Identification of a novel human gene, ZFP91, involved in acute myelogenous leukemia". International Journal of Oncology 22.6 (2003): 1217-1223.
Chicago
Unoki, M., Okutsu, J., Nakamura, Y."Identification of a novel human gene, ZFP91, involved in acute myelogenous leukemia". International Journal of Oncology 22, no. 6 (2003): 1217-1223. https://doi.org/10.3892/ijo.22.6.1217