Systemic delivery of RafsiRNA using cationic cardiolipin liposomes silences Raf-1 expression and inhibits tumor growth in xenograft model of human prostate cancer

  • Authors: Ajai Pal, Ateeq Ahmad, Sumsullah Khan, Isamu Sakabe, Chuanbo Zhang, Usha N. Kasid, Imran Ahmad
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  • Published online on: Friday, April 1, 2005
  • Pages: 1087-1091
  • DOI: 10.3892/ijo.26.4.1087

Abstract

Raf-1, a protein serine-threonine kinase, plays a critical role in mitogen-activated protein kinase kinase (MKK/MEK)- mitogen-activated protein kinase (extracellular signal-regulated kinase) (MAPK/ERK) pathways. We show here that systemically delivered novel cationic cardiolipin liposomes (NeoPhectin-ATâ„¢) containing a small interfering RNA (siRNA) against Raf-1 silence the expression of Raf-1 in tumor tissues and inhibit tumor growth in xenograft model of human prostate cancer. The knockdown of Raf-1 expression by siRNA is also associated with down-regulation of cyclin D1 expression in vivo.
Journal Cover

April 2005
Volume 26 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

2012 Impact Factor: 2.657
Ranked #31/196 Oncology
(total number of cites)

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APA
Pal, A., Ahmad, A., Khan, S., Sakabe, I., Zhang, C., Kasid, U., & Ahmad, I. (2005). Systemic delivery of RafsiRNA using cationic cardiolipin liposomes silences Raf-1 expression and inhibits tumor growth in xenograft model of human prostate cancer. International Journal of Oncology, 26(4), 1087-1091.
MLA
Pal, Ahmad, Khan, Sakabe, Zhang, Kasid, and Imran Ahmad. "Systemic delivery of RafsiRNA using cationic cardiolipin liposomes silences Raf-1 expression and inhibits tumor growth in xenograft model of human prostate cancer." International Journal of Oncology International Journal of Oncology 26.4 (2005): 1087-1091.
Chicago
Pal, Ahmad, Khan, Sakabe, Zhang, Kasid, and Imran Ahmad. "Systemic delivery of RafsiRNA using cationic cardiolipin liposomes silences Raf-1 expression and inhibits tumor growth in xenograft model of human prostate cancer." International Journal of Oncology International Journal of Oncology 26 no. 4 (2005): 1087-1091.