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Systemic delivery of RafsiRNA using cationic cardiolipin liposomes silences Raf-1 expression and inhibits tumor growth in xenograft model of human prostate cancer

  • Authors:
    • Ajai Pal
    • Ateeq Ahmad
    • Sumsullah Khan
    • Isamu Sakabe
    • Chuanbo Zhang
    • Usha N. Kasid
    • Imran Ahmad

  • View Affiliations

  • Published online on: April 1, 2005     https://doi.org/10.3892/ijo.26.4.1087
  • Pages: 1087-1091
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Abstract

Raf-1, a protein serine-threonine kinase, plays a critical role in mitogen-activated protein kinase kinase (MKK/MEK)- mitogen-activated protein kinase (extracellular signal-regulated kinase) (MAPK/ERK) pathways. We show here that systemically delivered novel cationic cardiolipin liposomes (NeoPhectin-AT™) containing a small interfering RNA (siRNA) against Raf-1 silence the expression of Raf-1 in tumor tissues and inhibit tumor growth in xenograft model of human prostate cancer. The knockdown of Raf-1 expression by siRNA is also associated with down-regulation of cyclin D1 expression in vivo.

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Journal Cover

April 2005
Volume 26 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • Journal Metrics
  • Impact Factor: 5.2
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 11.4
  • CiteScore Rank: Q1: #40/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 1.125
  • SCImago Journal Rank (SJR): 1.105
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Spandidos Publications style
Pal A, Ahmad A, Khan S, Sakabe I, Zhang C, Kasid UN and Ahmad I: Systemic delivery of RafsiRNA using cationic cardiolipin liposomes silences Raf-1 expression and inhibits tumor growth in xenograft model of human prostate cancer. Int J Oncol 26: 1087-1091, 2005
APA
Pal, A., Ahmad, A., Khan, S., Sakabe, I., Zhang, C., Kasid, U.N., & Ahmad, I. (2005). Systemic delivery of RafsiRNA using cationic cardiolipin liposomes silences Raf-1 expression and inhibits tumor growth in xenograft model of human prostate cancer. International Journal of Oncology, 26, 1087-1091. https://doi.org/10.3892/ijo.26.4.1087
MLA
Pal, A., Ahmad, A., Khan, S., Sakabe, I., Zhang, C., Kasid, U. N., Ahmad, I."Systemic delivery of RafsiRNA using cationic cardiolipin liposomes silences Raf-1 expression and inhibits tumor growth in xenograft model of human prostate cancer". International Journal of Oncology 26.4 (2005): 1087-1091.
Chicago
Pal, A., Ahmad, A., Khan, S., Sakabe, I., Zhang, C., Kasid, U. N., Ahmad, I."Systemic delivery of RafsiRNA using cationic cardiolipin liposomes silences Raf-1 expression and inhibits tumor growth in xenograft model of human prostate cancer". International Journal of Oncology 26, no. 4 (2005): 1087-1091. https://doi.org/10.3892/ijo.26.4.1087