Expression of bone morphogenetic protein 2 in breast cancer cells inhibits hypoxic cell death

  • Authors: Martin Raida, Joachim H. Clement, Kurosh Ameri, Cheng Han, Russell D. Leek, Adrian. L. Harris
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  • Published online on: Wednesday, June 1, 2005
  • Pages: 1465-1470
  • DOI: 10.3892/ijo.26.6.1465

Abstract

BMP-2 is involved in the fetal and postnatal development of the mammary gland but has also been detected in breast cancer cells. To clarify the biological role of BMP-2 in breast cancer, we used the human breast cancer cell line MCF-7. Incubation with BMP-2 under serum-free conditions induced activation of the mitogen activated protein kinases (MAPKs) ERK1/2 and the basic helix-loop-helix transcription factors Id-1, proteins that can protect from apoptosis. Stably transfected MCF-7 cells overexpressing BMP-2 revealed significantly increased resistance to hypoxia-induced apoptosis compared to empty vector controls. Cytoplasmic BMP-2/4 protein expression was detected in carcinoma cells of 81 samples of invasive breast cancer in contrast to adjacent normal mammary epithelial cells. BMP-2/4 expression did not correlate with common prognostic parameters and was not associated with relapse-free or overall survival. We conclude that BMP-2/4 expression is reactivated in invasive breast cancer and part of an autocrine/paracrine mechanism rescuing malignant cells from hypoxic cell death via activation of the MAPK and Id-1 pathway.
Journal Cover

June 2005
Volume 26 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

2013 Impact Factor: 2.773
Ranked #30/202 Oncology
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APA
Raida, M., Clement, J., Ameri, K., Han, C., Leek, R., & Harris, A. (2005). Expression of bone morphogenetic protein 2 in breast cancer cells inhibits hypoxic cell death. International Journal of Oncology, 26(6), 1465-1470.
MLA
Raida, Clement, Ameri, Han, Leek, and Adrian. Harris. "Expression of bone morphogenetic protein 2 in breast cancer cells inhibits hypoxic cell death." International Journal of Oncology International Journal of Oncology 26.6 (2005): 1465-1470.
Chicago
Raida, Clement, Ameri, Han, Leek, and Adrian. Harris. "Expression of bone morphogenetic protein 2 in breast cancer cells inhibits hypoxic cell death." International Journal of Oncology International Journal of Oncology 26 no. 6 (2005): 1465-1470.