Plasminogen activator/plasmin system suppresses cell-cell adhesion of oral squamous cell carcinoma cells via proteolysis of E-cadherin

  • Authors:
    • Yasutaka Hayashido
    • Tomoaki Hamana
    • Yukio Yoshioka
    • Hisataka Kitano
    • Koh-Ichi Koizumi
    • Tetsuji Okamoto
  • Corresponding author:
  • View Affiliations

  • Published online on: Thursday, September 1, 2005
  • Pages: 693-698 DOI: 10.3892/ijo.27.3.693

Abstract

The participation of plasminogen activator/plasmin system in the expression and function of E-cadherin was examined in oral squamous cell carcinoma (SCC) cells. Treatment of SCC cells with plasminogen reduced the Ca2+-dependent cell aggregation. SCC cells expressed E-cadherin at the cell membrane, and released a small amount of soluble E-cadherin at 80 kDa in the culture medium. Addition of plasminogen to SCC cells led to a decrease in the amount of E-cadherin of the cell membrane and the enhancement of the shedding of E-cadherin ectodomain. Plasmin directly cleaved E-cadherin of SCC cells and enhanced the motility of SCC cells. These results suggested that plasminogen activator/plasmin system might directly mediate the proteolytic processing of E-cadherin in oral SCC cells and that might facilitate the progression of oral SCC by downregulation of E-cadherin-mediated cell-cell adhesion.
Journal Cover

September 2005
Volume 27 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

2013 Impact Factor: 2.773
2014 I.F. (Expected) ≥ 3.310 Ranked #30/202 Oncology
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APA
Hayashido, Y., Hamana, T., Yoshioka, Y., Kitano, H., Koizumi, K., & Okamoto, T. (2005). Plasminogen activator/plasmin system suppresses cell-cell adhesion of oral squamous cell carcinoma cells via proteolysis of E-cadherin. International Journal of Oncology, 27, 693-698. http://dx.doi.org/10.3892/ijo.27.3.693
MLA
Hayashido, Y., Hamana, T., Yoshioka, Y., Kitano, H., Koizumi, K., Okamoto, T."Plasminogen activator/plasmin system suppresses cell-cell adhesion of oral squamous cell carcinoma cells via proteolysis of E-cadherin". International Journal of Oncology 27.3 (2005): 693-698.
Chicago
Hayashido, Y., Hamana, T., Yoshioka, Y., Kitano, H., Koizumi, K., Okamoto, T."Plasminogen activator/plasmin system suppresses cell-cell adhesion of oral squamous cell carcinoma cells via proteolysis of E-cadherin". International Journal of Oncology 27, no. 3 (2005): 693-698. http://dx.doi.org/10.3892/ijo.27.3.693