How to best classify breast cancer: Conventional and novel classifications (Review)

  • Authors: Emmanuelle Charafe-Jauffret, Christophe Ginestier, Florence Monville, Samira Fekairi, Jocelyne Jacquemier, Daniel Birnbaum, François Bertucci
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  • Published online on: Tuesday, November 1, 2005
  • Pages: 1307-1313
  • DOI: 10.3892/ijo.27.5.1307

Abstract

Breast cancer is a complex disease and different classifications, mostly based on clinical and pathological features, have been used for guiding the management of patients. Most of them fail to reflect breast cancer heterogeneity, which could be the reason why the treatment fails in approximately 30% of cases. Emerging molecular studies based on gene expression profiling using DNA microarrays have defined new molecular subtypes of breast cancer associated with the cell-of-origin distinction. Thus, breast cancer has been divided into five subgroups with distinct biological features and clinical outcomes. We have tried here to confront the conventional existing classifications with this new molecular taxonomy. It is likely that using all types of classification together will help in the management of breast cancer.
Journal Cover

November 2005
Volume 27 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

2013 Impact Factor: 2.773
Ranked #30/202 Oncology
(total number of cites)

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APA
Charafe-Jauffret, E., Ginestier, C., Monville, F., Fekairi, S., Jacquemier, J., Birnbaum, D., & Bertucci, F. (2005). How to best classify breast cancer: Conventional and novel classifications (Review). International Journal of Oncology, 27(5), 1307-1313.
MLA
Charafe-Jauffret, Ginestier, Monville, Fekairi, Jacquemier, Birnbaum, and François Bertucci. "How to best classify breast cancer: Conventional and novel classifications (Review)." International Journal of Oncology International Journal of Oncology 27.5 (2005): 1307-1313.
Chicago
Charafe-Jauffret, Ginestier, Monville, Fekairi, Jacquemier, Birnbaum, and François Bertucci. "How to best classify breast cancer: Conventional and novel classifications (Review)." International Journal of Oncology International Journal of Oncology 27 no. 5 (2005): 1307-1313.