EXPRESSION AND REGULATION OF THE 67-KDA LAMININ-BINDING PROTEIN AND ITS PRECURSOR GENE IN LYMPHOID-CELLS

  • Authors: H SUZUKI, X ZHANG, ME SOBEL, N KONDOH, TS PAPAS, NK BHAT
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  • Published online on: Wednesday, December 1, 1993
  • Pages: 1049-1056
  • DOI: 10.3892/ijo.3.6.1049

Abstract

The 67-kDa laminin-binding protein is a non-integrin laminin-binding protein that mediates cancer cell adhesion and migration. The expression of the 67-kDa laminin-binding protein and of its putative precursor, a 37-kDa polypeptide, was studied in peripheral T-cells and T-lymphoma cell lines. Immunofluorescence experiments detected antigen in both the cytosol and on the cell membrane. On immunoblots of T-cell protein extracts, both the 37-kDa precursor and the mature 67-kDa protein were present. The mRNA for the precursor was expressed in both immature and mature thymocytes. In three independent T-lymphoma cell lines, the mRNA levels were decreased after prolonged stimulation with phorbol esters. Since the latter directly activate protein kinase C, it appears that regulation of the 37-kDa precursor in T-cells may be mediated by the signal transduction cascade associated with protein kinase C activation.
Journal Cover

December 1993
Volume 3 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

2012 Impact Factor: 2.657
Ranked #31/196 Oncology
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APA
SUZUKI, H., ZHANG, X., SOBEL, M., KONDOH, N., PAPAS, T., & BHAT, N. (1993). EXPRESSION AND REGULATION OF THE 67-KDA LAMININ-BINDING PROTEIN AND ITS PRECURSOR GENE IN LYMPHOID-CELLS. International Journal of Oncology, 3(6), 1049-1056.
MLA
SUZUKI, ZHANG, SOBEL, KONDOH, PAPAS, and NK BHAT. "EXPRESSION AND REGULATION OF THE 67-KDA LAMININ-BINDING PROTEIN AND ITS PRECURSOR GENE IN LYMPHOID-CELLS." International Journal of Oncology International Journal of Oncology 3.6 (1993): 1049-1056.
Chicago
SUZUKI, ZHANG, SOBEL, KONDOH, PAPAS, and NK BHAT. "EXPRESSION AND REGULATION OF THE 67-KDA LAMININ-BINDING PROTEIN AND ITS PRECURSOR GENE IN LYMPHOID-CELLS." International Journal of Oncology International Journal of Oncology 3 no. 6 (1993): 1049-1056.