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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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April 2007 Volume 30 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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April 2007 Volume 30 Issue 4

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Article

Dexamethasone as a chemosensitizer for breast cancer chemotherapy: Potentiation of the antitumor activity of adriamycin, modulation of cytokine expression, and pharmacokinetics

  • Authors:
    • Hui Wang
    • Ying Wang
    • Elizabeth R. Rayburn
    • Donald L. Hill
    • John J. Rinehart
    • Ruiwen Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, AL 35294-0019, USA. hui.wang@ccc.uab.edu
  • Pages: 947-953
    |
    Published online on: April 1, 2007
       https://doi.org/10.3892/ijo.30.4.947
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Abstract

Dexamethasone (DEX) is mainly used as an anti-emetic agent in cancer therapy. We have recently demonstrated that DEX pretreatment increases the antitumor activity of the cancer chemotherapeutic agents carboplatin and gemcitabine, and decreases host toxicity in nude mouse xenograft models of human cancer. However, the underlying mechanisms are not fully understood. The present study was designed to determine the effects of DEX pretreatment on the anticancer activity of adriamycin (ADR) in a syngeneic model of breast cancer (4T1), emphasizing the effects of DEX on cytokine expression and modulation of ADR pharmacokinetics. We have demonstrated five major new findings about DEX pretreatment: a) it enhances the therapeutic effect of ADR, inducing almost complete inhibition of tumor growth; b) it increases tumor ADR accumulation; c) it modulates the expression of cytokines produced by the tumor, increasing TNFα and decreasing IL-1β and VEGF expression; d) it enhances the effects of ADR on induction of apoptosis and inhibition of cell proliferation; and e) it suppresses nuclear NFκB activation and inhibits ADR-induced NFκB activation, possibly via IκB up-regulation. These findings suggest that DEX can be used as a chemosensitizer and chemoprotectant. These results provide a rationale for the expanded clinical use of DEX for cancer therapy.

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Copy and paste a formatted citation
Spandidos Publications style
Wang H, Wang Y, Rayburn ER, Hill DL, Rinehart JJ and Zhang R: Dexamethasone as a chemosensitizer for breast cancer chemotherapy: Potentiation of the antitumor activity of adriamycin, modulation of cytokine expression, and pharmacokinetics. Int J Oncol 30: 947-953, 2007.
APA
Wang, H., Wang, Y., Rayburn, E.R., Hill, D.L., Rinehart, J.J., & Zhang, R. (2007). Dexamethasone as a chemosensitizer for breast cancer chemotherapy: Potentiation of the antitumor activity of adriamycin, modulation of cytokine expression, and pharmacokinetics. International Journal of Oncology, 30, 947-953. https://doi.org/10.3892/ijo.30.4.947
MLA
Wang, H., Wang, Y., Rayburn, E. R., Hill, D. L., Rinehart, J. J., Zhang, R."Dexamethasone as a chemosensitizer for breast cancer chemotherapy: Potentiation of the antitumor activity of adriamycin, modulation of cytokine expression, and pharmacokinetics". International Journal of Oncology 30.4 (2007): 947-953.
Chicago
Wang, H., Wang, Y., Rayburn, E. R., Hill, D. L., Rinehart, J. J., Zhang, R."Dexamethasone as a chemosensitizer for breast cancer chemotherapy: Potentiation of the antitumor activity of adriamycin, modulation of cytokine expression, and pharmacokinetics". International Journal of Oncology 30, no. 4 (2007): 947-953. https://doi.org/10.3892/ijo.30.4.947
Copy and paste a formatted citation
x
Spandidos Publications style
Wang H, Wang Y, Rayburn ER, Hill DL, Rinehart JJ and Zhang R: Dexamethasone as a chemosensitizer for breast cancer chemotherapy: Potentiation of the antitumor activity of adriamycin, modulation of cytokine expression, and pharmacokinetics. Int J Oncol 30: 947-953, 2007.
APA
Wang, H., Wang, Y., Rayburn, E.R., Hill, D.L., Rinehart, J.J., & Zhang, R. (2007). Dexamethasone as a chemosensitizer for breast cancer chemotherapy: Potentiation of the antitumor activity of adriamycin, modulation of cytokine expression, and pharmacokinetics. International Journal of Oncology, 30, 947-953. https://doi.org/10.3892/ijo.30.4.947
MLA
Wang, H., Wang, Y., Rayburn, E. R., Hill, D. L., Rinehart, J. J., Zhang, R."Dexamethasone as a chemosensitizer for breast cancer chemotherapy: Potentiation of the antitumor activity of adriamycin, modulation of cytokine expression, and pharmacokinetics". International Journal of Oncology 30.4 (2007): 947-953.
Chicago
Wang, H., Wang, Y., Rayburn, E. R., Hill, D. L., Rinehart, J. J., Zhang, R."Dexamethasone as a chemosensitizer for breast cancer chemotherapy: Potentiation of the antitumor activity of adriamycin, modulation of cytokine expression, and pharmacokinetics". International Journal of Oncology 30, no. 4 (2007): 947-953. https://doi.org/10.3892/ijo.30.4.947
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