Prognostic value of human telomerase reverse transcriptase gene expression in oral carcinogenesis

  • Authors:
    • G. Pannone
    • S. De Maria
    • R. Zamparese
    • S. Metafora
    • R. Serpico
    • F. Morelli
    • C. Rubini
    • E. Farina
    • M. Carteni
    • S. Staibano
    • G. De Rosa
    • L. Lo Muzio
    • P. Bufo
  • View Affiliations

  • Published online on: June 1, 2007     https://doi.org/10.3892/ijo.30.6.1349
  • Pages: 1349-1357
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Abstract

Human telomerase reverse transcriptase (hTERT) gene expression in resected specimens of oral squamous cell carcinoma (OSCC) and their surrounding tissue, either apparently normal or clearly histologically dysplastic, was evaluated by both real-time RT-PCR and immunohisto-chemical protein analyses. The expression level of hTERT in oral dysplasia and in OSCC was markedly higher than in normal tissues. The correlation between hTERT expression in OSCC and clinico-pathological parameters or survival of OSCC patients was statistically analyzed. Our study demonstrates that there is no significant relationship between hTERT expression and classical clinico-pathological parameters. Interestingly, survival analysis showed both overexpressing cases and lower survival rate in the early stage of OSCC (p=0.03 for immunohistochemistry; p=0.04 for RT real-time PCR). The histological location of hTERT in these tumors has been discussed in the context of the cancer stem cell theory.

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June 2007
Volume 30 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Pannone G, De Maria S, Zamparese R, Metafora S, Serpico R, Morelli F, Rubini C, Farina E, Carteni , Staibano S, Staibano S, et al: Prognostic value of human telomerase reverse transcriptase gene expression in oral carcinogenesis. Int J Oncol 30: 1349-1357, 2007.
APA
Pannone, G., De Maria, S., Zamparese, R., Metafora, S., Serpico, R., Morelli, F. ... Bufo, P. (2007). Prognostic value of human telomerase reverse transcriptase gene expression in oral carcinogenesis. International Journal of Oncology, 30, 1349-1357. https://doi.org/10.3892/ijo.30.6.1349
MLA
Pannone, G., De Maria, S., Zamparese, R., Metafora, S., Serpico, R., Morelli, F., Rubini, C., Farina, E., Carteni, ., Staibano, S., De Rosa, G., Lo Muzio, L., Bufo, P."Prognostic value of human telomerase reverse transcriptase gene expression in oral carcinogenesis". International Journal of Oncology 30.6 (2007): 1349-1357.
Chicago
Pannone, G., De Maria, S., Zamparese, R., Metafora, S., Serpico, R., Morelli, F., Rubini, C., Farina, E., Carteni, ., Staibano, S., De Rosa, G., Lo Muzio, L., Bufo, P."Prognostic value of human telomerase reverse transcriptase gene expression in oral carcinogenesis". International Journal of Oncology 30, no. 6 (2007): 1349-1357. https://doi.org/10.3892/ijo.30.6.1349