Clinical significance of growth differentiation factor 11 in colorectal cancer

  • Authors: Takeshi Yokoe, Takahiro Ohmachi, Hiroshi Inoue, Koshi Mimori, Fumiaki Tanaka, Masato Kusunoki, Masaki Mori
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  • Published online on: Thursday, November 1, 2007
  • Pages: 1097-1101
  • DOI: 10.3892/ijo.31.5.1097

Abstract

Growth differentiation factor 11 (GDF11), a member of the transforming growth factor-β superfamily and bone morphogenetic protein (BMP) subfamily, plays a role in regulation of development and differentiation. Although some members of BMP subfamily have been reported to correlate with cancer, the significance of GDF11 has not been studied in a clinical oncology setting. The current study explored the clinicopathological significance of GDF11 expression in colorectal cancer. Quantitative real-time reverse transcription-PCR in colorectal cancer specimens obtained from 130 patients showed that GDF11 mRNA expression in cancer tissue was significantly higher than in normal tissue (p=0.001). Tumors were classified as high GDF11 expression (n=65) or low GDF11 expression (n=65). Patients whose tumors had high GDF11 expression showed a high frequency of lymph node metastasis (p=0.049) and had more cancer-related deaths (p=0.040). Furthermore, the patients with high GDF11 expression had significantly poorer overall survival than those with low expression (p=0.0334). Although multivariate analysis showed that GDF11 was not an independent prognostic factor, these findings suggest that GDF11 may be a novel diagnostic and prognostic biomarker in patients with colorectal cancer.
Journal Cover

November 2007
Volume 31 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

2012 Impact Factor: 2.657
Ranked #31/196 Oncology
(total number of cites)

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APA
Yokoe, T., Ohmachi, T., Inoue, H., Mimori, K., Tanaka, F., Kusunoki, M., & Mori, M. (2007). Clinical significance of growth differentiation factor 11 in colorectal cancer. International Journal of Oncology, 31(5), 1097-1101.
MLA
Yokoe, Ohmachi, Inoue, Mimori, Tanaka, Kusunoki, and Masaki Mori. "Clinical significance of growth differentiation factor 11 in colorectal cancer." International Journal of Oncology International Journal of Oncology 31.5 (2007): 1097-1101.
Chicago
Yokoe, Ohmachi, Inoue, Mimori, Tanaka, Kusunoki, and Masaki Mori. "Clinical significance of growth differentiation factor 11 in colorectal cancer." International Journal of Oncology International Journal of Oncology 31 no. 5 (2007): 1097-1101.