Clinical significance of growth differentiation factor 11 in colorectal cancer

  • Authors:
    • Takeshi Yokoe
    • Takahiro Ohmachi
    • Hiroshi Inoue
    • Koshi Mimori
    • Fumiaki Tanaka
    • Masato Kusunoki
    • Masaki Mori
  • Corresponding author:
  • View Affiliations

  • Published online on: Thursday, November 1, 2007
  • Pages: 1097-1101 DOI: 10.3892/ijo.31.5.1097

Abstract

Growth differentiation factor 11 (GDF11), a member of the transforming growth factor-β superfamily and bone morphogenetic protein (BMP) subfamily, plays a role in regulation of development and differentiation. Although some members of BMP subfamily have been reported to correlate with cancer, the significance of GDF11 has not been studied in a clinical oncology setting. The current study explored the clinicopathological significance of GDF11 expression in colorectal cancer. Quantitative real-time reverse transcription-PCR in colorectal cancer specimens obtained from 130 patients showed that GDF11 mRNA expression in cancer tissue was significantly higher than in normal tissue (p=0.001). Tumors were classified as high GDF11 expression (n=65) or low GDF11 expression (n=65). Patients whose tumors had high GDF11 expression showed a high frequency of lymph node metastasis (p=0.049) and had more cancer-related deaths (p=0.040). Furthermore, the patients with high GDF11 expression had significantly poorer overall survival than those with low expression (p=0.0334). Although multivariate analysis showed that GDF11 was not an independent prognostic factor, these findings suggest that GDF11 may be a novel diagnostic and prognostic biomarker in patients with colorectal cancer.
Journal Cover

November 2007
Volume 31 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

2013 Impact Factor: 2.773
2014 I.F. (Expected) ≥ 3.258 Ranked #30/202 Oncology
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APA
Yokoe, T., Ohmachi, T., Inoue, H., Mimori, K., Tanaka, F., Kusunoki, M., & Mori, M. (2007). Clinical significance of growth differentiation factor 11 in colorectal cancer. International Journal of Oncology, 31, 1097-1101. http://dx.doi.org/10.3892/ijo.31.5.1097
MLA
Yokoe, T., Ohmachi, T., Inoue, H., Mimori, K., Tanaka, F., Kusunoki, M., Mori, M."Clinical significance of growth differentiation factor 11 in colorectal cancer". International Journal of Oncology 31.5 (2007): 1097-1101.
Chicago
Yokoe, T., Ohmachi, T., Inoue, H., Mimori, K., Tanaka, F., Kusunoki, M., Mori, M."Clinical significance of growth differentiation factor 11 in colorectal cancer". International Journal of Oncology 31, no. 5 (2007): 1097-1101. http://dx.doi.org/10.3892/ijo.31.5.1097