HIV-1 Tat enhances replicative potential of human oral keratinocytes harboring HPV-16 genome

  • Authors:
    • Reuben H. Kim
    • Ji Min Yochim
    • Mo K. Kang
    • Ki-Hyuk Shin
    • Russell Christensen
    • No-Hee Park
  • Corresponding author:
  • View Affiliations

  • Published online on: Wednesday, October 1, 2008
  • Pages: 777-782 DOI: 10.3892/ijo_00000064

Abstract

Introducing highly active antiretroviral therapy (HAART) has significantly decreased the morbidity and mortality in human immunodeficiency virus-positive (HIV+) individuals by decreasing the viral loads and increasing the CD4+ T-cell counts. Subsequently, the occurrence of many HIV-associated diseases has been dramatically declined except human papillomavirus (HPV)-associated lesions. Such notion suggests that immune response is not a major determinant, and that the direct interaction between HIV and HPV may be involved in the HPV-associated pathogenesis. In the current study, we investigated whether HIV plays a direct role in HPV-associated oral carcinogenesis by using HIV-1 transactivator protein (Tat), which is known to have oncogenic properties. We found that HIV-1 Tat not only increased the expression of HPV-16 E6 and E7 oncogenes in human oral keratinocytes harboring the HPV type-16 genome (HOK-16B), but also notably enhanced the proliferative capacity of the cells in vitro. Moreover, HOK-16B cells expressing HIV-1 Tat was capable of inducing cystic nodules in nude mice, while the control HOK-16B cells failed to produce nodules in the mice. Our results indicate that HIV could play a role in the HPV-associated pathogenesis by exerting oncogenic stimulus via Tat protein.
Journal Cover

October 2008
Volume 33 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

2013 Impact Factor: 2.773
2014 I.F. (Expected) ≥ 3.310 Ranked #30/202 Oncology
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APA
Kim, R.H., Yochim, J.M., Kang, M.K., Shin, K., Christensen, R., & Park, N. (2008). HIV-1 Tat enhances replicative potential of human oral keratinocytes harboring HPV-16 genome. International Journal of Oncology, 33, 777-782. http://dx.doi.org/10.3892/ijo_00000064
MLA
Kim, R. H., Yochim, J. M., Kang, M. K., Shin, K., Christensen, R., Park, N."HIV-1 Tat enhances replicative potential of human oral keratinocytes harboring HPV-16 genome". International Journal of Oncology 33.4 (2008): 777-782.
Chicago
Kim, R. H., Yochim, J. M., Kang, M. K., Shin, K., Christensen, R., Park, N."HIV-1 Tat enhances replicative potential of human oral keratinocytes harboring HPV-16 genome". International Journal of Oncology 33, no. 4 (2008): 777-782. http://dx.doi.org/10.3892/ijo_00000064