Biochemical effects of piceatannol in human HL-60 promyelocytic leukemia cells - synergism with Ara-C

  • Authors: Monika Fritzer-Szekeres, Ivo Savinc, Zsuzsanna Horvath, Philipp Saiko, Michael Pemberger, Geraldine Graser, Astrid Bernhaus, Maria Ozsvar-Kozma, Michael Grusch, Walter Jaeger, Thomas Szekeres
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  • Published online on: Wednesday, October 1, 2008
  • Pages: 887-892
  • DOI: 10.3892/ijo_00000077

Abstract

Piceatannol (3,3',4,5'-tetrahydroxy-trans-stilbene; PCA) is a naturally occurring metabolite of resveratrol (3,4',5-trihydroxy-trans-stilbene; RV). In this study, we identified additional biochemical targets of PCA in human HL-60 promyelocytic leukemia cells. Incubation with PCA led to a significant proportion of apoptotic cells and caused an arrest in the G2-M phase of the cell cycle. PCA depleted intracellular dCTP and dGTP pools, and inhibited the incorporation of 14C-labeled cytidine into DNA. PCA significantly abolished all NTP pools, and sequential treatment with PCA and Ara-C yielded synergistic growth inhibitory effects because of remarkably increased Ara-CTP formation after PCA preincubation. Due to these promising results, PCA may support conventional chemotherapy of human malignancies and therefore, deserves further preclinical and in vivo testing.
Journal Cover

October 2008
Volume 33 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

2012 Impact Factor: 2.657
Ranked #31/196 Oncology
(total number of cites)

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APA
Fritzer-Szekeres, M., Savinc, I., Horvath, Z., Saiko, P., Pemberger, M., Graser, G., Bernhaus, A., Ozsvar-Kozma, M., Grusch, M., Jaeger, W., & Szekeres, T. (2008). Biochemical effects of piceatannol in human HL-60 promyelocytic leukemia cells - synergism with Ara-C. International Journal of Oncology, 33(4), 887-892.
MLA
Fritzer-Szekeres, Savinc, Horvath, Saiko, Pemberger, Graser, Bernhaus, Ozsvar-Kozma, Grusch, Jaeger, and Thomas Szekeres. "Biochemical effects of piceatannol in human HL-60 promyelocytic leukemia cells - synergism with Ara-C." International Journal of Oncology International Journal of Oncology 33.4 (2008): 887-892.
Chicago
Fritzer-Szekeres, Savinc, Horvath, Saiko, Pemberger, Graser, Bernhaus, Ozsvar-Kozma, Grusch, Jaeger, and Thomas Szekeres. "Biochemical effects of piceatannol in human HL-60 promyelocytic leukemia cells - synergism with Ara-C." International Journal of Oncology International Journal of Oncology 33 no. 4 (2008): 887-892.