Biochemical effects of piceatannol in human HL-60 promyelocytic leukemia cells - synergism with Ara-C

  • Authors:
    • Monika Fritzer-Szekeres
    • Ivo Savinc
    • Zsuzsanna Horvath
    • Philipp Saiko
    • Michael Pemberger
    • Geraldine Graser
    • Astrid Bernhaus
    • Maria Ozsvar-Kozma
    • Michael Grusch
    • Walter Jaeger
    • Thomas Szekeres
  • View Affiliations

  • Published online on: October 1, 2008     https://doi.org/10.3892/ijo_00000077
  • Pages: 887-892
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Abstract

Piceatannol (3,3',4,5'-tetrahydroxy-trans-stilbene; PCA) is a naturally occurring metabolite of resveratrol (3,4',5-trihydroxy-trans-stilbene; RV). In this study, we identified additional biochemical targets of PCA in human HL-60 promyelocytic leukemia cells. Incubation with PCA led to a significant proportion of apoptotic cells and caused an arrest in the G2-M phase of the cell cycle. PCA depleted intracellular dCTP and dGTP pools, and inhibited the incorporation of 14C-labeled cytidine into DNA. PCA significantly abolished all NTP pools, and sequential treatment with PCA and Ara-C yielded synergistic growth inhibitory effects because of remarkably increased Ara-CTP formation after PCA preincubation. Due to these promising results, PCA may support conventional chemotherapy of human malignancies and therefore, deserves further preclinical and in vivo testing.

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October 2008
Volume 33 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Fritzer-Szekeres M, Savinc I, Horvath Z, Saiko P, Pemberger M, Graser G, Bernhaus A, Ozsvar-Kozma M, Grusch M, Jaeger W, Jaeger W, et al: Biochemical effects of piceatannol in human HL-60 promyelocytic leukemia cells - synergism with Ara-C. Int J Oncol 33: 887-892, 2008.
APA
Fritzer-Szekeres, M., Savinc, I., Horvath, Z., Saiko, P., Pemberger, M., Graser, G. ... Szekeres, T. (2008). Biochemical effects of piceatannol in human HL-60 promyelocytic leukemia cells - synergism with Ara-C. International Journal of Oncology, 33, 887-892. https://doi.org/10.3892/ijo_00000077
MLA
Fritzer-Szekeres, M., Savinc, I., Horvath, Z., Saiko, P., Pemberger, M., Graser, G., Bernhaus, A., Ozsvar-Kozma, M., Grusch, M., Jaeger, W., Szekeres, T."Biochemical effects of piceatannol in human HL-60 promyelocytic leukemia cells - synergism with Ara-C". International Journal of Oncology 33.4 (2008): 887-892.
Chicago
Fritzer-Szekeres, M., Savinc, I., Horvath, Z., Saiko, P., Pemberger, M., Graser, G., Bernhaus, A., Ozsvar-Kozma, M., Grusch, M., Jaeger, W., Szekeres, T."Biochemical effects of piceatannol in human HL-60 promyelocytic leukemia cells - synergism with Ara-C". International Journal of Oncology 33, no. 4 (2008): 887-892. https://doi.org/10.3892/ijo_00000077