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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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February 2010 Volume 36 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February 2010 Volume 36 Issue 2

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Article

Cytotoxic effects of ultra-diluted remedies on breast cancer cells

  • Authors:
    • Moshe Frenkel
    • Bal Mukund Mishra
    • Subrata Sen
    • Peiying Yang
    • Alison Pawlus
    • Luis Vence
    • Aimee Leblanc
    • Lorenzo Cohen
    • Pratip Banerji
    • Prasanta Banerji

  • View Affiliations / Copyright

    Affiliations: Integrative Medicine Program-Unit 145, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030-4009, USA. frenkelm@netvision.net.il
  • Pages: 395-403
    |
    Published online on: February 1, 2010
       https://doi.org/10.3892/ijo_00000512
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Abstract

The use of ultra-diluted natural products in the management of disease and treatment of cancer has generated a lot of interest and controversy. We conducted an in vitro study to determine if products prescribed by a clinic in India have any effect on breast cancer cell lines. We studied four ultra-diluted remedies (Carcinosin, Phytolacca, Conium and Thuja) against two human breast adenocarcinoma cell lines (MCF-7 and MDA-MB-231) and a cell line derived from immortalized normal human mammary epithelial cells (HMLE). The remedies exerted preferential cytotoxic effects against the two breast cancer cell lines, causing cell cycle delay/arrest and apoptosis. These effects were accompanied by altered expression of the cell cycle regulatory proteins, including downregulation of phosphorylated Rb and upregulation of the CDK inhibitor p27, which were likely responsible for the cell cycle delay/arrest as well as induction of the apoptotic cascade that manifested in the activation of caspase 7 and cleavage of PARP in the treated cells. The findings demonstrate biological activity of these natural products when presented at ultra-diluted doses. Further in-depth studies with additional cell lines and animal models are warranted to explore the clinical applicability of these agents.

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Copy and paste a formatted citation
Spandidos Publications style
Frenkel M, Mishra BM, Sen S, Yang P, Pawlus A, Vence L, Leblanc A, Cohen L, Banerji P, Banerji P, Banerji P, et al: Cytotoxic effects of ultra-diluted remedies on breast cancer cells. Int J Oncol 36: 395-403, 2010.
APA
Frenkel, M., Mishra, B.M., Sen, S., Yang, P., Pawlus, A., Vence, L. ... Banerji, P. (2010). Cytotoxic effects of ultra-diluted remedies on breast cancer cells. International Journal of Oncology, 36, 395-403. https://doi.org/10.3892/ijo_00000512
MLA
Frenkel, M., Mishra, B. M., Sen, S., Yang, P., Pawlus, A., Vence, L., Leblanc, A., Cohen, L., Banerji, P., Banerji, P."Cytotoxic effects of ultra-diluted remedies on breast cancer cells". International Journal of Oncology 36.2 (2010): 395-403.
Chicago
Frenkel, M., Mishra, B. M., Sen, S., Yang, P., Pawlus, A., Vence, L., Leblanc, A., Cohen, L., Banerji, P., Banerji, P."Cytotoxic effects of ultra-diluted remedies on breast cancer cells". International Journal of Oncology 36, no. 2 (2010): 395-403. https://doi.org/10.3892/ijo_00000512
Copy and paste a formatted citation
x
Spandidos Publications style
Frenkel M, Mishra BM, Sen S, Yang P, Pawlus A, Vence L, Leblanc A, Cohen L, Banerji P, Banerji P, Banerji P, et al: Cytotoxic effects of ultra-diluted remedies on breast cancer cells. Int J Oncol 36: 395-403, 2010.
APA
Frenkel, M., Mishra, B.M., Sen, S., Yang, P., Pawlus, A., Vence, L. ... Banerji, P. (2010). Cytotoxic effects of ultra-diluted remedies on breast cancer cells. International Journal of Oncology, 36, 395-403. https://doi.org/10.3892/ijo_00000512
MLA
Frenkel, M., Mishra, B. M., Sen, S., Yang, P., Pawlus, A., Vence, L., Leblanc, A., Cohen, L., Banerji, P., Banerji, P."Cytotoxic effects of ultra-diluted remedies on breast cancer cells". International Journal of Oncology 36.2 (2010): 395-403.
Chicago
Frenkel, M., Mishra, B. M., Sen, S., Yang, P., Pawlus, A., Vence, L., Leblanc, A., Cohen, L., Banerji, P., Banerji, P."Cytotoxic effects of ultra-diluted remedies on breast cancer cells". International Journal of Oncology 36, no. 2 (2010): 395-403. https://doi.org/10.3892/ijo_00000512
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