Xanthohumol, a prenylated chalcone derived from hops, inhibits proliferation, migration and interleukin-8 expression of hepatocellular carcinoma cells

  • Authors: Christoph Dorn, Thomas S. Weiss, Jörg Heilmann, Claus Hellerbrand
  • View Affiliations

  • Published online on: Monday, February 1, 2010
  • Pages: 435-441
  • DOI: 10.3892/ijo_00000517

Abstract

Xanthohumol, the major prenylated chalcone found in hops, is well known to exert anti-cancer effects, but information regarding the impact on hepatocellular carcinoma (HCC) cells and potential adverse effects on non-tumorous hepatocytes is limited. Here, we show that xanthohumol at a concentration of 25 µM induced apoptosis in two HCC cell lines (HepG2 and Huh7). Furthermore, xanthohumol repressed proliferation and migration, as well as TNF induced NF-κB activity and interleukin-8 expression in both cell lines at even lower concentrations. In contrast, xanthohumol concentrations up to 100 µM did not affect viability of primary human hepatocytes in vitro. In summary, our data showed that xanthohumol can ameliorate different pro-tumorigenic mechanisms known to promote HCC progression, indicating its potential as promising therapeutic agent that selectively affects cancer cells.
Journal Cover

February 2010
Volume 36 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

2013 Impact Factor: 2.773
Ranked #30/202 Oncology
(total number of cites)

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APA
Dorn, C., Weiss, T., Heilmann, J., & Hellerbrand, C. (2010). Xanthohumol, a prenylated chalcone derived from hops, inhibits proliferation, migration and interleukin-8 expression of hepatocellular carcinoma cells. International Journal of Oncology, 36(2), 435-441.
MLA
Dorn, Weiss, Heilmann, and Claus Hellerbrand. "Xanthohumol, a prenylated chalcone derived from hops, inhibits proliferation, migration and interleukin-8 expression of hepatocellular carcinoma cells." International Journal of Oncology International Journal of Oncology 36.2 (2010): 435-441.
Chicago
Dorn, Weiss, Heilmann, and Claus Hellerbrand. "Xanthohumol, a prenylated chalcone derived from hops, inhibits proliferation, migration and interleukin-8 expression of hepatocellular carcinoma cells." International Journal of Oncology International Journal of Oncology 36 no. 2 (2010): 435-441.