Influence of HPV16 E2 and its localisation on the expression of matrix metalloproteinase-9

  • Authors: Sabrina Mühlen, Andreas Behren, Thomas Iftner, Christian Simon
  • View Affiliations

  • Published online on: Sunday, August 1, 2010
  • Pages: 337-345
  • DOI: 10.3892/ijo_00000682

Abstract

Infection with the high-risk HPV types 16 and 18 is the major cause of cervical cancer and plays a role in the development of certain head and neck and skin cancers. We have previously demonstrated that the Early Protein 2 of the Cottontail Rabbit papillomavirus (CRPV), required for skin carcinogenesis in a rabbit model, is able to induce the expression of a matrix metalloproteinase (MMP-9); a protease known to play a key role in invasion and metastasis. However, as of now we do not understand the underlying mechanism of activation nor relevance for the human system. Here, we report that high-risk human papillomavirus HPV16 E2 similar to our previously reported results on CRPV E2 activates the human MMP-9 promoter predominantly via the MEK1-ERK1/2-AP-1-signaling pathway. In addition this activation is associated with a nuclear sub-localisation of HPV16-E2 suggesting a nuclear protein-protein or protein-DNA interaction of E2 as the underlying mechanism of activation.
Journal Cover

August 2010
Volume 37 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

2012 Impact Factor: 2.657
Ranked #31/196 Oncology
(total number of cites)

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APA
Mühlen, S., Behren, A., Iftner, T., & Simon, C. (2010). Influence of HPV16 E2 and its localisation on the expression of matrix metalloproteinase-9. International Journal of Oncology, 37(2), 337-345.
MLA
Mühlen, Behren, Iftner, and Christian Simon. "Influence of HPV16 E2 and its localisation on the expression of matrix metalloproteinase-9." International Journal of Oncology International Journal of Oncology 37.2 (2010): 337-345.
Chicago
Mühlen, Behren, Iftner, and Christian Simon. "Influence of HPV16 E2 and its localisation on the expression of matrix metalloproteinase-9." International Journal of Oncology International Journal of Oncology 37 no. 2 (2010): 337-345.