Parthenolide treatment activates stress signaling proteins in high-risk acute lymphoblastic leukemia cells with chromosomal translocation t(4;11)

  • Authors:
    • Susan J. Zunino
    • David H. Storms
    • Jonathan M. Ducore
  • View Affiliations

  • Published online on: Monday, November 1, 2010
  • Pages: 1307-1313
  • DOI: 10.3892/ijo_00000782

Abstract

Parthenolide, the principal bio-active component of the herb feverfew (Tanacetum parthenium), has shown anti-leukemic activity. We evaluated the cell cycle status and the phosphorylation/activation of proteins involved in signal transduction in t(4;11) and non-t(4;11) acute lymphoblastic leukemia (ALL) cell lines after treatment with parthenolide. The cells were treated with the vehicle or 10 ┬ÁM parthenolide for 2, 4, 6 and 8 h. As shown by flow cytometric analysis, parthenolide induced growth arrest at the S to G2/M phase transition. Using multiplex technology and Western blotting, we showed that the treatment with parthenolide within 0 to 10 h induced the phosphorylation of stress signaling proteins, including the p38 mitogen-activated protein kinase, the c-Jun N-terminal kinase, c-Jun, the heat shock protein 27 and protein kinase B. These data show that parthenolide induces a stress response leading to cell death and provide further evidence suggesting that parthenolide could be useful as a novel therapeutic agent against high risk ALL with chromosomal translocation t(4;11).
Journal Cover

November 2010
Volume 37 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

2013 Impact Factor: 2.773
Ranked #30/202 Oncology
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APA
Zunino, S., Storms, D., & Ducore, J. (2010). Parthenolide treatment activates stress signaling proteins in high-risk acute lymphoblastic leukemia cells with chromosomal translocation t(4;11). International Journal of Oncology, 37(5), 1307-1313.
MLA
Zunino, Storms, and Jonathan Ducore. "Parthenolide treatment activates stress signaling proteins in high-risk acute lymphoblastic leukemia cells with chromosomal translocation t(4;11)." International Journal of Oncology International Journal of Oncology 37.5 (2010): 1307-1313.
Chicago
Zunino, Storms, and Jonathan Ducore. "Parthenolide treatment activates stress signaling proteins in high-risk acute lymphoblastic leukemia cells with chromosomal translocation t(4;11)." International Journal of Oncology International Journal of Oncology 37 no. 5 (2010): 1307-1313.