Ganoderma lucidum exerts anti-tumor effects on ovarian cancer cells and enhances their sensitivity to cisplatin

  • Authors: Sufen Zhao, Gang Ye, Guodong Fu, Jian-Xin Cheng, Burton B. Yang, Chun Peng
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  • Published online on: Tuesday, March 8, 2011
  • Pages: 1319-1327
  • DOI: 10.3892/ijo.2011.965

Abstract

Ganoderma lucidum is a herbal mushroom known to have many health benefits, including the inhibition of tumor cell growth. However, the effect of Ganoderma lucidum on epithelial ovarian cancer (EOC), the most fatal gynecological malignancy, has not yet been reported. In this study, we determined whether Ganoderma lucidum regulates EOC cell activity. Using several cell lines derived from EOC, we found that Ganoderma lucidum strongly decreased cell numbers in a dose-dependent manner. Ganoderma lucidum also inhibited colony formation, cell migration and spheroid formation. In particular, Ganoderma lucidum was effective in inhibiting cell growth in both chemosensitive and chemoresistant cells and the treatment with Ganoderma lucidum significantly enhanced the effect of cisplatin on EOC cells. Furthermore, Ganoderma lucidum induced cell cycle arrest at the G2/M phase and also induced apoptosis by activating caspase 3. Finally, Ganoderma lucidum increased p53 but inhibited Akt expression. Taken together, these findings suggest that Ganoderma lucidum exerts multiple anti-tumor effects on ovarian cancer cells and can enhance the sensitivity of EOC cells to cisplatin.
Journal Cover

May 2011
Volume 38 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

2012 Impact Factor: 2.773
Ranked #30/202 Oncology
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APA
Zhao, S., Ye, G., Fu, G., Cheng, J., Yang, B., & Peng, C. (2011). Ganoderma lucidum exerts anti-tumor effects on ovarian cancer cells and enhances their sensitivity to cisplatin. International Journal of Oncology, 38(5), 1319-1327.
MLA
Zhao, Ye, Fu, Cheng, Yang, and Chun Peng. "Ganoderma lucidum exerts anti-tumor effects on ovarian cancer cells and enhances their sensitivity to cisplatin." International Journal of Oncology International Journal of Oncology 38.5 (2011): 1319-1327.
Chicago
Zhao, Ye, Fu, Cheng, Yang, and Chun Peng. "Ganoderma lucidum exerts anti-tumor effects on ovarian cancer cells and enhances their sensitivity to cisplatin." International Journal of Oncology International Journal of Oncology 38 no. 5 (2011): 1319-1327.