Estrogen inhibits the effects of obesity and alcohol on mammary tumors and fatty liver

  • Authors: Jina Hong, Valerie B. Holcomb, Kyoko Kushiro, Nomelí P. Núñez
  • View Affiliations

  • Published online on: Wednesday, August 17, 2011
  • Pages: 1443-1453
  • DOI: 10.3892/ijo.2011.1162

Abstract

The risk of developing breast cancer and fatty liver is increased by alcohol consumption. The objective of the present study was to determine if obesity and exogenous estrogen supplementation alter the effects of alcohol on mammary tumorigenesis and fatty liver. Ovariectomized female mice were (1) fed diets to induce overweight and obese phenotypes, (2) provided water or 20% alcohol, (3) implanted with placebo, low- or high-dose estrogen pellets and (4) injected with Met-1 mouse mammary cancer cells. Alcohol-consuming mice were more insulin sensitive and developed larger tumors than water consuming mice. Obese mice developed slightly larger tumors than control mice. Alcohol consumption and obesity increased growth factors, hepatic steatosis, activation of Akt, and inhibited the caspase-3 cascade. Estrogen treatment triggered the loss of body fat, induced insulin sensitivity, suppressed tumor growth, reduced growth factors and improved hepatic steatosis. Results show that the effects of alcohol on mammary tumor and fatty liver are modified by obesity and estrogen supplementation.
Journal Cover

December 2011
Volume 39 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

2012 Impact Factor: 2.657
Ranked #31/196 Oncology
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APA
Hong, J., Holcomb, V., Kushiro, K., & Núñez, N. (2011). Estrogen inhibits the effects of obesity and alcohol on mammary tumors and fatty liver. International Journal of Oncology, 39(6), 1443-1453.
MLA
Hong, Holcomb, Kushiro, and Nomelí Núñez. "Estrogen inhibits the effects of obesity and alcohol on mammary tumors and fatty liver." International Journal of Oncology International Journal of Oncology 39.6 (2011): 1443-1453.
Chicago
Hong, Holcomb, Kushiro, and Nomelí Núñez. "Estrogen inhibits the effects of obesity and alcohol on mammary tumors and fatty liver." International Journal of Oncology International Journal of Oncology 39 no. 6 (2011): 1443-1453.