Open Access

ProstaCaid™ inhibits tumor growth in a xenograft model of human prostate cancer

  • Authors: Jiahua Jiang, Jagadish Loganathan, Isaac Eliaz, Colin Terry, George E. Sandusky, Daniel Sliva
  • View Affiliations

  • Published online on: Tuesday, January 24, 2012
  • Pages: 1339-1344
  • DOI: 10.3892/ijo.2012.1344

Abstract

We have recently demonstrated that the dietary supplement ProstaCaid™ (PC) inhibits growth and invasive behavior of PC-3 human prostate cancer cells in vitro. In the present study, we evaluated toxicity and whether PC suppresses growth of prostate cancer in a xenograft model of human prostate cancer cells implanted in mice. Here, we show that an oral administration of PC (100, 200 and 400 mg/kg) did not affect body weight or activity of liver enzymes (ALT, AST) and did not show any sign of toxicity in liver, spleen, kidney, lung and heart tissues in mice. In addition, PC treatment resulted in the inhibition of tumor volumes (1024.6±378.6 vs. 749.3±234.3, P<0.001) in a xenograft model of prostate cancer with human hormone refractory (independent) PC-3 prostate cancer cells. Moreover, qRT-PCR analysis demonstrated significant upregulation of expression of CDKN1A (p21) and inhibition of expression of IGF2, NR2F2 and PLAU (uPA) genes by an oral administration of PC in prostate cancer xenografts. Our study demonstrates that the concentrations of the dietary supplement ProstaCaid tested did not show signs of toxicity, and its oral application has significant anticancer activity in vivo and can be considered as an alternative treatment for prostate cancer patients.
Journal Cover

May 2012
Volume 40 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

2012 Impact Factor: 2.773
Ranked #30/202 Oncology
(total number of cites)

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APA
Jiang, J., Loganathan, J., Eliaz, I., Terry, C., Sandusky, G., & Sliva, D. (2012). ProstaCaid™ inhibits tumor growth in a xenograft model of human prostate cancer. International Journal of Oncology, 40(5), 1339-1344.
MLA
Jiang, Loganathan, Eliaz, Terry, Sandusky, and Daniel Sliva. "ProstaCaid™ inhibits tumor growth in a xenograft model of human prostate cancer." International Journal of Oncology International Journal of Oncology 40.5 (2012): 1339-1344.
Chicago
Jiang, Loganathan, Eliaz, Terry, Sandusky, and Daniel Sliva. "ProstaCaid™ inhibits tumor growth in a xenograft model of human prostate cancer." International Journal of Oncology International Journal of Oncology 40 no. 5 (2012): 1339-1344.