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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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July 2012 Volume 41 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2012 Volume 41 Issue 1

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Article

Berberine inhibits the proliferation of colon cancer cells by inactivating Wnt/β-catenin signaling

  • Authors:
    • Ke Wu
    • Qiujun Yang
    • Yuqin Mu
    • Longyang Zhou
    • Yinzi Liu
    • Qixin Zhou
    • Baicheng He

  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology, Chongqing Medical University, Chongqing 400016, P.R. China, Department of pharmacology, Chongqing Medical University, Chongqing 400016, P.R. China
  • Pages: 292-298
    |
    Published online on: April 2, 2012
       https://doi.org/10.3892/ijo.2012.1423
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Abstract

Colon cancer is one of the most common malignancies, mainly initiated by the abnormal activation of Wnt/β-catenin signaling. In this study, we investigated the proliferation inhibitory effect of berberine on colon cancer cells and the molecular basis underlying this effect. With the viability, apoptosis and cell cycle assay, we demonstrated that berberine can inhibit proliferation, induce apoptosis and cell cycle arrest in colon cancer cells. In in vivo investigation, we demonstrated that berberine can prevent the colon cancer formation initiated by dimethylhydrazine (DMH) and dextran sodium sulfate (DSS) in rats. We employed western blotting, reverse transcription and polymerase chain reaction, special antagonist, overexpression and knockdown techniques to dissect the possible molecular mechanisms mediating the function of berberine. We found that the protein levels of β-catenin in the nucleus and cytoplasm were all reduced after treating the colon cancer cells with berberine, and this may not result from accelerating the degradation of β-catenin in the cytoplasm, but from inhibiting the mRNA expression of β-catenin. Our results indicate that berberine can be a potential chemoprevention and chemotherapy agent for human colon cancer by targeting Wnt/β-catenin signaling.

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Copy and paste a formatted citation
Spandidos Publications style
Wu K, Yang Q, Mu Y, Zhou L, Liu Y, Zhou Q and He B: Berberine inhibits the proliferation of colon cancer cells by inactivating Wnt/β-catenin signaling. Int J Oncol 41: 292-298, 2012.
APA
Wu, K., Yang, Q., Mu, Y., Zhou, L., Liu, Y., Zhou, Q., & He, B. (2012). Berberine inhibits the proliferation of colon cancer cells by inactivating Wnt/β-catenin signaling. International Journal of Oncology, 41, 292-298. https://doi.org/10.3892/ijo.2012.1423
MLA
Wu, K., Yang, Q., Mu, Y., Zhou, L., Liu, Y., Zhou, Q., He, B."Berberine inhibits the proliferation of colon cancer cells by inactivating Wnt/β-catenin signaling". International Journal of Oncology 41.1 (2012): 292-298.
Chicago
Wu, K., Yang, Q., Mu, Y., Zhou, L., Liu, Y., Zhou, Q., He, B."Berberine inhibits the proliferation of colon cancer cells by inactivating Wnt/β-catenin signaling". International Journal of Oncology 41, no. 1 (2012): 292-298. https://doi.org/10.3892/ijo.2012.1423
Copy and paste a formatted citation
x
Spandidos Publications style
Wu K, Yang Q, Mu Y, Zhou L, Liu Y, Zhou Q and He B: Berberine inhibits the proliferation of colon cancer cells by inactivating Wnt/β-catenin signaling. Int J Oncol 41: 292-298, 2012.
APA
Wu, K., Yang, Q., Mu, Y., Zhou, L., Liu, Y., Zhou, Q., & He, B. (2012). Berberine inhibits the proliferation of colon cancer cells by inactivating Wnt/β-catenin signaling. International Journal of Oncology, 41, 292-298. https://doi.org/10.3892/ijo.2012.1423
MLA
Wu, K., Yang, Q., Mu, Y., Zhou, L., Liu, Y., Zhou, Q., He, B."Berberine inhibits the proliferation of colon cancer cells by inactivating Wnt/β-catenin signaling". International Journal of Oncology 41.1 (2012): 292-298.
Chicago
Wu, K., Yang, Q., Mu, Y., Zhou, L., Liu, Y., Zhou, Q., He, B."Berberine inhibits the proliferation of colon cancer cells by inactivating Wnt/β-catenin signaling". International Journal of Oncology 41, no. 1 (2012): 292-298. https://doi.org/10.3892/ijo.2012.1423
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