The pathobiological impact of cigarette smoke on pancreatic cancer development (Review)

  • Authors:
    • Uwe A. Wittel
    • Navneet Momi
    • Gabriel Seifert
    • Thorsten Wiech
    • Ulrich T. Hopt
    • Surinder K. Batra
  • View Affiliations

  • Published online on: Friday, March 23, 2012
  • Pages: 5-14
  • DOI: 10.3892/ijo.2012.1414

Abstract

Despite extensive efforts, pancreatic cancer remains incurable. Most risk factors, such as genetic disposition, metabolic diseases or chronic pancreatitis cannot be influenced. By contrast, cigarette smoking, an important risk factor for pancreatic cancer, can be controlled. Despite the epidemiological evidence of the detrimental effects of cigarette smoking with regard to pancreatic cancer development and its unique property of being influenceable, our understanding of cigarette smoke-induced pancreatic carcinogenesis is limited. Current data on cigarette smoke-induced pancreatic carcinogenesis indicate multifactorial events that are triggered by nicotine, which is the major pharmacologically active constituent of tobacco smoke. In addition to nicotine, a vast number of carcinogens have the potential to reach the pancreatic gland, where they are metabolized, in some instances to even more toxic compounds. These metabolic events are not restricted to pancreatic ductal cells. Several studies show that acinar cells are also greatly affected. Furthermore, pancreatic cancer progenitor cells do not only derive from the ductal epithelial lineage, but also from acinar cells. This sheds new light on cigarette smoke-induced acinar cell damage. On this background, our objective is to outline a multifactorial model of tobacco smoke-induced pancreatic carcinogenesis.
Journal Cover

July 2012
Volume 41 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

2013 Impact Factor: 2.773
Ranked #30/202 Oncology
(total number of cites)

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APA
Wittel, U., Momi, N., Seifert, G., Wiech, T., Hopt, U., & Batra, S. (2012). The pathobiological impact of cigarette smoke on pancreatic cancer development (Review). International Journal of Oncology, 41(1), 5-14.
MLA
Wittel, Momi, Seifert, Wiech, Hopt, and Surinder Batra. "The pathobiological impact of cigarette smoke on pancreatic cancer development (Review)." International Journal of Oncology International Journal of Oncology 41.1 (2012): 5-14.
Chicago
Wittel, Momi, Seifert, Wiech, Hopt, and Surinder Batra. "The pathobiological impact of cigarette smoke on pancreatic cancer development (Review)." International Journal of Oncology International Journal of Oncology 41 no. 1 (2012): 5-14.