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2010 Impact Factor: 2.571
Journal Citation Reports®
Thomson 2011

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Early Online Publication

Spandidos Publication’s Early Online feature allows for the publication of articles online before they appear in print. The Early Online articles are listed below in order of publication date. The online publication date appears below each title, followed by the article’s unique Digital Object Identifier (DOI).
Learn more about Early Online articles.

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Pathway simulations in common oncogenic drivers of leukemic and rhabdomyosarcoma cells: A systems biology approach
George I. Lambrou, Apostolos Zaravinos, Maria Adamaki, Demetrios  A. Spandidos, Fotini Tzortzatou-Stathopoulou, Spiros Vlachopoulos
Published online on: Tuesday, February 7, 2012 Doi: 10.3892/ijo.2012.1361
Characterization of a novel mouse monoclonal antibody, clone 1E8.33, highly specific for human procollagen 11A1, a tumor-associated stromal component
Marcos García-Ocaña, Fernando Vázquez, Carmen García-Pravia, Nelson Fuentes-Martínez, Primitiva Menéndez-Rodríguez, Florentino Fresno-Forcelledo, Luis Barneo-Serra, Jokin Del Amo-Iribarren, Laureano Simón-Buela, Juan R. De Los Toyos
Published online on: Tuesday, February 7, 2012 Doi: 10.3892/ijo.2012.1360
Aspirin enhances doxorubicin-induced apoptosis and reduces tumor growth in human hepatocellular carcinoma cells in vitro and in vivo
Mohammad Akbar Hossain, Dong Hwan Kim, Jung Yoon Jang, Yong Jung Kang, Jeong-Hyun Yoon, Jeon-Ok Moon, Hae Young Chung, Gi-Young Kim, Yung Hyun Choi, Bryan L. Copple, Nam Deuk Kim
Published online on: Tuesday, February 7, 2012 Doi: 10.3892/ijo.2012.1359
New alternatively spliced variant of prostate-specific membrane antigen PSM-E suppresses the proliferation, migration and invasiveness of prostate cancer cells
Kai-Yuan Cao, Lin Xu, Ding-Mei Zhang, Xiao-Ming Zhang, Tian Zhang, Xia He, Zhu Wang, Fa-Shen Feng, Shao-Peng Qiu, Guan-Xin Shen
Published online on: Monday, February 6, 2012 Doi: 10.3892/ijo.2012.1358
Significant systemic therapeutic effects of high-LET immunoradiation by 212Pb-trastuzumab against prostatic tumors of androgen-independent human prostate cancer in mice
Zongqing Tan, Pingping Chen, Nathan Schneider, Samuel Glover, Lingling Cui, Julien Torgue, Olivier Rixe, Henry B. Spitz, Zhongyun Dong
Published online on: Monday, February 6, 2012 Doi: 10.3892/ijo.2012.1357
Structural analysis of the EGFR TK domain and potential implications for EGFR targeted therapy
Weiwei Nie, Lin Tang, Haiyang Zhang, Jiaqing Shao, Yucai Wang, Longbang Chen, Donghai Li, Xiaoxiang Guan
Published online on: Friday, February 3, 2012 Doi: 10.3892/ijo.2012.1356
Identification of blood protein biomarkers that aid in the clinical assessment of patients with malignant glioma
Baogang J. Xu, Qi A. An, Supriya Srinivasa Gowda, Wenwei Yan, Larry A. Pierce, Ty W. Abel, Sarah Z. Rush, Michael K. Cooper, Fei Ye, Yu Shyr, Kyle D. Weaver, Reid C. Thompson
Published online on: Friday, February 3, 2012 Doi: 10.3892/ijo.2012.1355
Synergistic effects of suberoylanilide hydroxamic acid combined with cisplatin causing cell cycle arrest independent apoptosis in platinum-resistant ovarian cancer cells
Pei-Shi Ong, Xin-Qiao Wang, Hai-Shu Lin, Sui-Yung Chan, Paul C. Ho
Published online on: Thursday, February 2, 2012 Doi: 10.3892/ijo.2012.1354
The anti-obesity drug orlistat promotes sensitivity to TRAIL by two different pathways in hormone-refractory prostate cancer cells
Jun Fujiwara, Yoshihiro Sowa, Mano Horinaka, Makoto Koyama, Miki Wakada, Tsuneharu Miki, Toshiyuki Sakai
Published online on: Thursday, February 2, 2012 Doi: 10.3892/ijo.2012.1353
A novel CD44v6 targeting antibody fragment with improved tumor-to-blood ratio
K. Sandström, A. K. Haylock, D. Spiegelberg, F. Qvarnström, K. Wester, M. Nestor
Published online on: Wednesday, February 1, 2012 Doi: 10.3892/ijo.2012.1352
Personalized peptide vaccination in patients with refractory non-small cell lung cancer
Koichi Yoshiyama, Yasuhiro Terazaki, Satoko Matsueda, Shigeki Shichijo, Masanori Noguchi, Akira Yamada, Takashi Mine, Tetsuya Ioji, Kyogo Itoh, Kazuo Shirouzu, Tetsuro Sasada, Shinzo Takamori
Published online on: Wednesday, February 1, 2012 Doi: 10.3892/ijo.2012.1351
Citrus aurantium L. exhibits apoptotic effects on U937 human leukemia cells partly through inhibition of Akt
Min Ho Han, Won Sup Lee, Jing Nan Lu, Gonsup Kim, Jin Myung Jung, Chung Ho Ryu, Gi-Young Kim, Hye Jin Hwang, Taeg Kyu Kwon, Yung Hyun Choi
Published online on: Wednesday, February 1, 2012 Doi: 10.3892/ijo.2012.1350

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Crucial cross-talk of interleukin-1β and progesterone in human choriocarcinoma
Elena Zachariades, Dionisis Mparmpakas, Peter Thomas, Mariann Rand-Weaver, Emmanouil Karteris
Published online on: Friday, January 27, 2012 Doi: 10.3892/ijo.2012.1349
Identification of genes potentially involved in bone metastasis by genome-wide gene expression profile analysis of non-small cell lung cancer in mice
Le Tan Dat, Taisuke Matsuo, Tetsuro Yoshimaru, Soji Kakiuchi, Hisatsugu Goto, Masaki Hanibuchi, Takuya Kuramoto, Yasuhiko Nishioka, Saburo Sone, Toyomasa Katagiri
Published online on: Friday, January 27, 2012 Doi: 10.3892/ijo.2012.1348

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Influence of a 50 Hz magnetic field and of all-trans‑retinol on the proliferation of human cancer cell lines
María Ángeles Trillo, María Antonia Martínez, María  Antonia Cid, Jocelyne Leal, Alejandro Úbeda
Published online on: Friday, January 27, 2012 Doi: 10.3892/ijo.2012.1347
Hypoxia and TP53 deficiency for induced pluripotent stem cell-like properties in gastrointestinal cancer
Hiromitsu Hoshino, Hiroaki Nagano, Naotsugu Haraguchi, Shimpei Nishikawa, Akira Tomokuni, Yoshihiro Kano, Takahito Fukusumi, Toshiyuki Saito, Miyuki Ozaki, Daisuke Sakai, Taroh Satoh, Hidetoshi Eguchi, Mitsugu Sekimoto, Yuichiro Doki, Masaki Mori, Hideshi Ishii
Published online on: Tuesday, January 24, 2012 Doi: 10.3892/ijo.2012.1346
Inhibition of cell viability by human IFN-β is mediated by microRNA-431
Takeshi Tanaka, Shigeru Sugaya, Kazuko Kita, Makoto Arai, Tatsuo Kanda, Katsunori Fujii, Fumio Imazeki, Katsuo Sugita, Osamu Yokosuka, Nobuo Suzuki
Published online on: Tuesday, January 24, 2012 Doi: 10.3892/ijo.2012.1345

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ProstaCaid™ inhibits tumor growth in a xenograft model of human prostate cancer
Jiahua Jiang, Jagadish Loganathan, Isaac Eliaz, Colin Terry, George E. Sandusky, Daniel Sliva
Published online on: Tuesday, January 24, 2012 Doi: 10.3892/ijo.2012.1344

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Preventive effect of caffeine and curcumin on hepato­carcinogenesis in diethylnitrosamine-induced rats
Yuki Fujise, Jun-Ichi Okano, Takakazu Nagahara, Ryo Abe, Ryu Imamoto, Yoshikazu Murawaki
Published online on: Tuesday, January 24, 2012 Doi: 10.3892/ijo.2012.1343
miR-10b promotes cell invasion through RhoC-AKT signaling pathway by targeting HOXD10 in gastric cancer
Zhuo Liu, Jiaming Zhu, Hong Cao, Hui Ren, Xuedong Fang
Published online on: Tuesday, January 24, 2012 Doi: 10.3892/ijo.2012.1342
Identification of prognostic biomarkers for response to radiotherapy by DNA microarray in nasopharyngeal carcinoma patients
Shu Yang, Jiaxin Chen, Yi Guo, Hui Lin, Zheng Zhang, Guosheng Feng, Yanrong Hao, Jinjian Cheng, Ping Liang, Kehe Chen, Hai Wu, Yao Li
Published online on: Friday, January 20, 2012 Doi: 10.3892/ijo.2012.1341
Blockade of TRPM8 activity reduces the invasion potential of oral squamous carcinoma cell lines
Yoshihiko Okamoto, Tsuyako Ohkubo, Tetsuro Ikebe, Jun Yamazaki
Published online on: Friday, January 20, 2012 Doi: 10.3892/ijo.2012.1340
Upregulated expression of ADAM12 is associated with progression of oral squamous cell carcinoma
Erika Uehara, Masashi Shiiba, Keiji Shinozuka, Kengo Saito, Yukinao Kouzu, Hirofumi Koike, Atsushi Kasamatsu, Yosuke Sakamoto, Katsunori Ogawara, Katsuhiro Uzawa, Hideki Tanzawa
Published online on: Friday, January 20, 2012 Doi: 10.3892/ijo.2012.1339
Downregulation of heparanase by RNA interference inhibits invasion and tumorigenesis of hepatocellular cancer cells in vitro and in vivo
Zhen Xiong, Mu-Han Lü, Ya-Han Fan, Ya-Ling Cao, Chang-Jiang Hu, Yu-Yun Wu, Shu-Min Wang, Gang Luo, Dian-Chun Fang, Chuan Li, Shi-Ming Yang
Published online on: Friday, January 20, 2012 Doi: 10.3892/ijo.2012.1338
Mucin production determines sensitivity to bortezomib and gemcitabine in pancreatic cancer cells
Thaddäus Till Wissniowski, Silke Meister, Eckhart G. Hahn, Joachim R. Kalden, Reinhard Voll, Matthias Ocker
Published online on: Wednesday, January 18, 2012 Doi: 10.3892/ijo.2012.1337
Expression analysis of Cdc42 in lung cancer and modulation of its expression by curcumin in lung cancer cell lines
Qing-Yong Chen, De-Min Jiao, Qing-Hua Yao, Jie Yan, Jia Song, Fang-Yuan Chen, Guo-Hua Lu, Jian-Ying Zhou
Published online on: Tuesday, January 17, 2012 Doi: 10.3892/ijo.2012.1336

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Nestin as a novel therapeutic target for pancreatic cancer via tumor angiogenesis
Kazuya Yamahatsu, Yoko Matsuda, Toshiyuki Ishiwata, Eiji Uchida, Zenya Naito
Published online on: Friday, January 13, 2012 Doi: 10.3892/ijo.2012.1333
Inhibition of migration and invasion of LNCaP human prostate carcinoma cells by cordycepin through inactivation of Akt
Jin-Woo Jeong, Cheng-Yun Jin, Cheol Park, Min Ho Han, Gi-Young Kim, Sung-Kwon Moon, Chan Gil Kim, Yong Kee Jeong, Wun-Jae Kim, Jae-Dong Lee, Yung Hyun Choi
Published online on: Friday, January 13, 2012 Doi: 10.3892/ijo.2012.1332
Puerarin suppresses production of nitric oxide and inducible nitric oxide synthase in lipopolysaccharide-induced N9 microglial cells through regulating MAPK phosphorylation, O-GlcNAcylation and NF-κB translocation
Gao-Ming Zheng, Chao Yu, Zhu Yang
Published online on: Friday, January 13, 2012 Doi: 10.3892/ijo.2012.1331
Millimeter wave treatment induces apoptosis via activation of the mitochondrial-dependent pathway in human osteosarcoma cells
Guangwen Wu, Xuzheng Chen, Jun Peng, Qiaoyan Cai, Jinxia Ye, Huifeng Xu, Chunsong Zheng, Xihai Li, Hongzhi Ye, Xianxiang Liu
Published online on: Thursday, January 12, 2012 Doi: 10.3892/ijo.2012.1330
Change in gene expression profiles of secreted frizzled-related proteins (SFRPs) by sodium butyrate in gastric cancers: Induction of promoter demethylation and histone modification causing inhibition of Wnt signaling
Hyunsoo Shin, Jie-Hyun Kim, Yeo Song Lee, Yong Chan Lee
Published online on: Tuesday, January 10, 2012 Doi: 10.3892/ijo.2012.1327
Pien Tze Huang inhibits tumor cell proliferation and promotes apoptosis via suppressing the STAT3 pathway in a colorectal cancer mouse model
Qunchuan Zhuang, Fei Hong, Aling Shen, Liangpu Zheng, Jianwei Zeng, Wei Lin, Youqin Chen, Thomas J. Sferra, Zhenfeng Hong, Jun Peng
Published online on: Tuesday, January 3, 2012 Doi: 10.3892/ijo.2012.1326

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Involvement of p21waf1/cip1 expression in the cytotoxicity of the potent histone deacetylase inhibitor spiruchostatin B towards susceptible NALM-6 human B cell leukemia cells
Syu-Ichi Kanno, Naoyuki Maeda, Ayako Tomizawa, Shin Yomogida, Tadashi Katoh, Masaaki Ishikawa
Published online on: Friday, December 30, 2011 Doi: 10.3892/ijo.2011.1323
ADAM17 targets MMP-2 and MMP-9 via EGFR-MEK-ERK pathway activation to promote prostate cancer cell invasion
Li-Jie Xiao, Ping Lin, Feng Lin, Xin Liu, Wei Qin, Hai-Feng Zou, Liang Guo, Wei Liu, Shu-Juan Wang, Xiao-Guang Yu
Published online on: Friday, December 23, 2011 Doi: 10.3892/ijo.2011.1320
Carboxyl-terminal modulator protein induces apoptosis by regulating mitochondrial function in lung cancer cells
Soon-Kyung Hwang, Arash Minai-Tehrani, Kyeong-Nam Yu, Seung-Hee Chang, Ji-Eun Kim, Kee-Ho Lee, Jongsun Park, George R. Beck Jr, Myung-Haing Cho
Published online on: Friday, December 23, 2011 Doi: 10.3892/ijo.2011.1319
Geraniol induces cooperative interaction of apoptosis and autophagy to elicit cell death in PC-3 prostate cancer cells
Su-Hwa Kim, Eun-Jung Park, Chae Ryun Lee, Jung Nyeo Chun, Nam-Hyuk Cho, In-Gyu Kim, Sanghoon Lee, Tae Woo Kim, Hyun Ho Park, Insuk So, Ju-Hong Jeon
Published online on: Friday, December 23, 2011 Doi: 10.3892/ijo.2011.1318
Norcantharidin: A potential antiangiogenic agent for gallbladder cancers in vitro and in vivo
Jing-Tao Zhang, Yue-Zu Fan, Chun-Qiu Chen, Zhe-Ming Zhao, Wei Sun
Published online on: Wednesday, December 21, 2011 Doi: 10.3892/ijo.2011.1314
Heat shock protein 90 is a promising target for effective growth inhibition of gastrointestinal neuroendocrine tumors
Christoph Gloesenkamp, Bianca Nitzsche, Alice R. Lim, Emmanuel Normant, Evan Vosburgh, Mark Schrader, Matthias Ocker, Hans Scherübl, Michael Höpfner
Published online on: Tuesday, January 10, 2012 Doi: 10.3892/ijo.2012.1328
Targeting cysteine-mediated dimerization of the MUC1-C oncoprotein in human cancer cells
Deepak Raina, Rehan Ahmad, Hasan Rajabi, Govind Panchamoorthy, Surender Kharbanda, Donald Kufe
Published online on: Tuesday, December 20, 2011 Doi: 10.3892/ijo.2011.1308
Protein interactions with HER-family receptors can have different characteristics depending on the hosting cell line
Pavel Barta, Jennie Malmberg, Ludmila Melicharova, John Strandgård, Anna Orlova, Vladimir Tolmachev, Milan Laznicek, Karl Andersson
Published online on: Monday, December 19, 2011 Doi: 10.3892/ijo.2011.1307
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