Shu‑Yu capsule, a Traditional Chinese Medicine formulation, attenuates premenstrual syndrome depression induced by chronic stress constraint

  • Authors:
    • Xingxiao Gao
    • Peng Sun
    • Mingqi Qiao
    • Sheng Wei
    • Ling Xue
    • Huiyun Zhang
  • View Affiliations

  • Published online on: September 26, 2014     https://doi.org/10.3892/mmr.2014.2599
  • Pages: 2942-2948
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The present study aimed to investigate the therapeutic effect of the Shu-Yu capsule (SYC), a Traditional Chinese Medicine formulation, on premenstrual syndrome (PMS) depression and the ratio of glutamate (Glu) to γ-aminobutyric acid (GABA) in a rat model of PMS depression. Rats were randomly divided into a control group, model group, fluoxetine group, SYC group and saikosaponins (SS) group. The therapeutic effect of SYC was evaluated using a sucrose preference test (SPT), open field test (OFT) and body mass following four days of treatment. Hippocampal extracellular fluid was collected by microdialysis and the levels of Glu and GABA in the microdialysate were measured by high performance liquid chromatography. The results revealed that, compared with the control group, the sucrose preference coefficient (SC%), total score of OFT and body mass of the model group were significantly lower (P<0.01, P<0.05 and P<0.01, respectively). However, the sucrose preference coefficient, total score of OFT and body mass of the SYC group were all significantly increased compared with the model group (P<0.05). Furthermore, SYC inhibited the decrease of the Glu/GABA ratio in the hippocampus of rats with PMS depression. It was concluded that SYC effectively improved the symptoms of PMS depression, possibly by inhibiting the dysregulation of the Glu/GABA balance in the central nervous system.
View Figures
View References

Related Articles

Journal Cover

December-2014
Volume 10 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Gao X, Sun P, Qiao M, Wei S, Xue L and Zhang H: Shu‑Yu capsule, a Traditional Chinese Medicine formulation, attenuates premenstrual syndrome depression induced by chronic stress constraint. Mol Med Rep 10: 2942-2948, 2014
APA
Gao, X., Sun, P., Qiao, M., Wei, S., Xue, L., & Zhang, H. (2014). Shu‑Yu capsule, a Traditional Chinese Medicine formulation, attenuates premenstrual syndrome depression induced by chronic stress constraint. Molecular Medicine Reports, 10, 2942-2948. https://doi.org/10.3892/mmr.2014.2599
MLA
Gao, X., Sun, P., Qiao, M., Wei, S., Xue, L., Zhang, H."Shu‑Yu capsule, a Traditional Chinese Medicine formulation, attenuates premenstrual syndrome depression induced by chronic stress constraint". Molecular Medicine Reports 10.6 (2014): 2942-2948.
Chicago
Gao, X., Sun, P., Qiao, M., Wei, S., Xue, L., Zhang, H."Shu‑Yu capsule, a Traditional Chinese Medicine formulation, attenuates premenstrual syndrome depression induced by chronic stress constraint". Molecular Medicine Reports 10, no. 6 (2014): 2942-2948. https://doi.org/10.3892/mmr.2014.2599