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Resveratrol inhibits the proliferation of human melanoma cells by inducing G1/S cell cycle arrest and apoptosis

  • Authors:
    • Zhiyuan Wu
    • Bin Liu
    • Cailing E
    • Jie Liu
    • Qingyu Zhang
    • Juntao  Liu
    • Nianping Chen
    • Rongyi Chen
    • Runzhi Zhu

  • View Affiliations

  • Published online on: October 21, 2014     https://doi.org/10.3892/mmr.2014.2716
  • Pages: 400-404
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

Resveratrol (Res), a natural plant extract, is an effective inducer of cell apoptosis and cell cycle arrest in multiple carcinoma cell types, which has been demonstrated by its ability to inhibit the proliferation of multiple human tumor cells in vitro. Although Res possesses chemopreventive properties against several types of cancer, the molecular mechanism underlying its anticancer activity remains to be fully elucidated. The present study demonstrated that Res induced cell cycle arrest and inhibited the proliferation of human melanoma A375 (IC50=23 µM after 48 h; P<0.05) and SK‑MEL‑31 (IC50=15 µM after 48 h; P<0.05) cells. Western blot analysis demonstrated that Res induced the apoptosis of human melanoma A375 and SK‑MEL‑31 cells by upregulating the expression of Bcl‑2‑associated X protein and B‑cell lymphoma 2, possibly via the p53 pathway and activation of caspase‑9 and caspase‑3.
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January-2015
Volume 11 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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  • Journal Metrics
  • Impact Factor: 3.4
  • Ranked Medicine Research and Experimental
    (total number of cites)
  • CiteScore: 6.9
  • CiteScore Rank: Q2: #98/328 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 0.721
  • SCImago Journal Rank (SJR): 0.65
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Spandidos Publications style
Wu Z, Liu B, E C, Liu J, Zhang Q, Liu J, Chen N, Chen R and Zhu R: Resveratrol inhibits the proliferation of human melanoma cells by inducing G1/S cell cycle arrest and apoptosis. Mol Med Rep 11: 400-404, 2015
APA
Wu, Z., Liu, B., E, C., Liu, J., Zhang, Q., Liu, J. ... Zhu, R. (2015). Resveratrol inhibits the proliferation of human melanoma cells by inducing G1/S cell cycle arrest and apoptosis. Molecular Medicine Reports, 11, 400-404. https://doi.org/10.3892/mmr.2014.2716
MLA
Wu, Z., Liu, B., E, C., Liu, J., Zhang, Q., Liu, J., Chen, N., Chen, R., Zhu, R."Resveratrol inhibits the proliferation of human melanoma cells by inducing G1/S cell cycle arrest and apoptosis". Molecular Medicine Reports 11.1 (2015): 400-404.
Chicago
Wu, Z., Liu, B., E, C., Liu, J., Zhang, Q., Liu, J., Chen, N., Chen, R., Zhu, R."Resveratrol inhibits the proliferation of human melanoma cells by inducing G1/S cell cycle arrest and apoptosis". Molecular Medicine Reports 11, no. 1 (2015): 400-404. https://doi.org/10.3892/mmr.2014.2716