Ectopic expression of B and T lymphocyte attenuator in gastric cancer: A potential independent prognostic factor in patients with gastric cancer

  • Authors:
    • Xing-Yu Feng
    • Xi-Zhi Wen
    • Xiao-Jing Tan
    • Jing-Hui Hou
    • Ya Ding
    • Ke‑Feng Wang
    • Jun Dong
    • Zhi-Wei Zhou
    • Ying-Bo Chen
    • Xiao-Shi Zhang
  • View Affiliations

  • Published online on: October 20, 2014     https://doi.org/10.3892/mmr.2014.2699
  • Pages: 658-664
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Abstract

It has been confirmed that B and T lymphocyte attenuator (BTLA; also known as CD272) is a novel co-­inhibitory molecule that exhibits a critical role in restraining cell-­mediated antitumor immunity. The present study aimed to investigate the expression and prognostic significance of BTLA in gastric adenocarcinoma. Immunohistochemical (IHC) staining was performed to investigate BTLA expression in gastric cancer tissues and normal mucosal tissues. In total, 123 pathologically confirmed specimens were obtained from stage IIIa gastric cancers. A correlation test, Kaplan-Meier curves, and a Cox proportional hazards regression model were used to analyze the data. No BTLA staining in the normal tissues was found, while BTLA-stained gastric carcinoma cells were detected in 75.6% (93/123) of the gastric cancer specimens. High expression levels of BTLA were detected in 31.7% (39/123) of the specimens, while low expression levels were detected in 68.3% (84/123) of the specimens. High BTLA expression levels were associated with shorter survival time, as confirmed by univariate and multivariate analyses. These findings provide a basis for the concept that high BTLA expression levels in gastric cancer, identified by IHC, are an independent biomarker for the poor prognosis of patients with gastric cancer.
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January-2015
Volume 11 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Feng X, Wen X, Tan X, Hou J, Ding Y, Wang KF, Dong J, Zhou Z, Chen Y, Zhang X, Zhang X, et al: Ectopic expression of B and T lymphocyte attenuator in gastric cancer: A potential independent prognostic factor in patients with gastric cancer. Mol Med Rep 11: 658-664, 2015
APA
Feng, X., Wen, X., Tan, X., Hou, J., Ding, Y., Wang, K. ... Zhang, X. (2015). Ectopic expression of B and T lymphocyte attenuator in gastric cancer: A potential independent prognostic factor in patients with gastric cancer. Molecular Medicine Reports, 11, 658-664. https://doi.org/10.3892/mmr.2014.2699
MLA
Feng, X., Wen, X., Tan, X., Hou, J., Ding, Y., Wang, K., Dong, J., Zhou, Z., Chen, Y., Zhang, X."Ectopic expression of B and T lymphocyte attenuator in gastric cancer: A potential independent prognostic factor in patients with gastric cancer". Molecular Medicine Reports 11.1 (2015): 658-664.
Chicago
Feng, X., Wen, X., Tan, X., Hou, J., Ding, Y., Wang, K., Dong, J., Zhou, Z., Chen, Y., Zhang, X."Ectopic expression of B and T lymphocyte attenuator in gastric cancer: A potential independent prognostic factor in patients with gastric cancer". Molecular Medicine Reports 11, no. 1 (2015): 658-664. https://doi.org/10.3892/mmr.2014.2699