Quantitative proteomic analysis of Down syndrome in the umbilical cord blood using iTRAQ

  • Authors:
    • Weiguo Sui
    • Ruohan Zhang
    • Jiejing Chen
    • Huiyan He
    • Zhenzhen Cui
    • Minglin Ou
    • Wuxian Li
    • Suwen Qi
    • Jingli Wen
    • Xiuhua Lin
    • Yong Dai
  • View Affiliations

  • Published online on: October 31, 2014     https://doi.org/10.3892/mmr.2014.2828
  • Pages: 1391-1399
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Abstract

Down sydrome (DS) is a relatively frequent chromosomal disorder, which has no safe and effective method of prenatal diagnosis to date. The present study was designed to identify DS biomarkers. We quantified the changes in the umbilical cord blood protein levels between DS-affected and healthy (control) pregnant females using isobaric tags for relative and absolute quantification (iTRAQ) and Gene Ontology (GO) analysis. A total of 505 proteins were identified, and of these, five proteins showed significantly different concentrations between the DS and the control group. These proteins may thus be relevant to DS and constitute potential DS biomarkers.
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February-2015
Volume 11 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Sui W, Zhang R, Chen J, He H, Cui Z, Ou M, Li W, Qi S, Wen J, Lin X, Lin X, et al: Quantitative proteomic analysis of Down syndrome in the umbilical cord blood using iTRAQ. Mol Med Rep 11: 1391-1399, 2015
APA
Sui, W., Zhang, R., Chen, J., He, H., Cui, Z., Ou, M. ... Dai, Y. (2015). Quantitative proteomic analysis of Down syndrome in the umbilical cord blood using iTRAQ. Molecular Medicine Reports, 11, 1391-1399. https://doi.org/10.3892/mmr.2014.2828
MLA
Sui, W., Zhang, R., Chen, J., He, H., Cui, Z., Ou, M., Li, W., Qi, S., Wen, J., Lin, X., Dai, Y."Quantitative proteomic analysis of Down syndrome in the umbilical cord blood using iTRAQ". Molecular Medicine Reports 11.2 (2015): 1391-1399.
Chicago
Sui, W., Zhang, R., Chen, J., He, H., Cui, Z., Ou, M., Li, W., Qi, S., Wen, J., Lin, X., Dai, Y."Quantitative proteomic analysis of Down syndrome in the umbilical cord blood using iTRAQ". Molecular Medicine Reports 11, no. 2 (2015): 1391-1399. https://doi.org/10.3892/mmr.2014.2828